Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.37 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13551473 | 0.87 | CYP2D6 (0.54) | CYP2D6LMNAMAPK1KMT2ASRC | |
| SCHEMBL3557022 | 0.87 | CYP2D6 (0.54) | CYP2D6LMNAMAPK1KMT2ASRC | |
| SCHEMBL25666225 | 0.75 | TSHR (0.71) | CYP2D6LMNAMAPK1KMT2ATP53 | |
| SCHEMBL25666223 | 0.75 | TSHR (0.71) | CYP2D6LMNAMAPK1KMT2ATP53 | |
| SCHEMBL1094149 | 0.73 | LMNA (0.46) | CYP2D6LMNAMAPK1SRCTSHR | |
| SCHEMBL7940900 | 0.73 | CYP2D6 (0.52) | CYP2D6LMNAMAPK1KMT2ASRC | |
| SCHEMBL7940904 | 0.73 | CYP2D6 (0.52) | CYP2D6LMNAMAPK1KMT2ASRC | |
| SCHEMBL18954122 | 0.72 | LMNA (0.45) | CYP2D6LMNAMAPK1KMT2ATSHR | |
| SCHEMBL6683066 | 0.71 | GABBR2 (0.44) | LMNAMAPK1KMT2APTGS1MAPT | |
| SCHEMBL10742661 | 0.71 | ADRA2C (0.54) | CYP2D6LMNATSHRADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158796-B2 | Process for the preparation of Rho-kinase inhibitor compounds | INSPIRE PHARMACEUTICALS, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-20100022775-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022775-A1 | PROCESS FOR THE PREPARATION OF RHO-KINASE INHIBITOR COMPOUNDS | ROCK1, ROCK2, RHOA | CYP2D6 2375/4885LMNA 1563/4885MAPK1 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.