Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | RAB9A | P51151 | 5/20 | 0.70 |
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3563360 | 0.80 | KMT2A (0.80) | NPC1RAB9APOLBCYP1A2CYP3A4 | |
| SCHEMBL13241783 | 0.73 | KMT2A (0.71) | NPC1RAB9APOLBCYP2C19SMN1; SMN2 | |
| SCHEMBL8986838 | 0.71 | NPC1 (0.62) | NPC1RAB9APOLBCYP1A2CYP3A4 | |
| SCHEMBL11207976 | 0.69 | KMT2A (0.62) | NPC1RAB9APOLBCYP1A2CYP3A4 | |
| SCHEMBL8986853 | 0.68 | NPC1 (0.57) | NPC1RAB9APOLBCYP1A2CYP3A4 | |
| SCHEMBL17498804 | 0.68 | ALDH1A1 (0.60) | NPC1RAB9APOLBSMN1; SMN2KMT2A | |
| SCHEMBL16158512 | 0.68 | POLB (0.57) | NPC1RAB9APOLBSMN1; SMN2KMT2A | |
| Water SCHEMBL8856485 | 0.67 | MAPT (0.52) | NPC1RAB9APOLBSMN1; SMN2KMT2A | |
| SCHEMBL12682342 | 0.66 | MAPT (0.71) | POLBCYP1A2CYP3A4CYP2C19TSHR | |
| SCHEMBL11244161 | 0.66 | PDE4D (0.81) | NPC1RAB9APOLBCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6103729-A | PREVENTION OR TREATMENT OF RESPIRATORY SYSTEM RELATED DISEASES, E.G., BRONCHIAL ASTHMA; ENZYME INHIBITOR OF PHOSPHODIESTERASE IV; ANTIINFLAMMATORY AND SPASMODIC AGENTS; RELAXANTS | CHEIL JEDANG CORP. (KR) | 2000-08-15 | — | — | US | disclosed |
| WO-1998023620-A1 | CATHECOL DERIVATIVES AND A METHOD FOR THE PREPARATION THEREOF AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | CHEIL JEDANG CORPORATION (KR) | 1998-06-04 | — | — | WO | disclosed |