Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.57 |
| ▸ | TNKS | O95271 | 1/20 | 0.57 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.57 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3565889 | 1.00 | KDM4E (0.59) | KDM4EALDH1A1PKMNPSR1HDAC4 | |
| SCHEMBL10021704 | 0.89 | HSD17B3 (0.61) | KDM4EALDH1A1PKMNPSR1HDAC4 | |
| SCHEMBL14968897 | 0.86 | KDM4E (0.56) | KDM4EALDH1A1PKMNPSR1HDAC4 | |
| SCHEMBL14968898 | 0.86 | KDM4E (0.56) | KDM4EALDH1A1PKMNPSR1HDAC4 | |
| SCHEMBL853485 | 0.84 | NPSR1 (0.61) | KDM4EALDH1A1PKMNPSR1HDAC4 | |
| SCHEMBL853486 | 0.84 | NPSR1 (0.61) | KDM4EALDH1A1PKMNPSR1HDAC4 | |
| SCHEMBL69146 | 0.82 | NPSR1 (0.74) | KDM4EALDH1A1PKMNPSR1HDAC4 | |
| SCHEMBL271386 | 0.82 | NPSR1 (0.74) | KDM4EALDH1A1PKMNPSR1HDAC4 | |
| SCHEMBL31380271 | 0.82 | TTR (0.53) | KDM4EALDH1A1SMN1; SMN2AKR1B10AKR1B1 | |
| SCHEMBL10509071 | 0.82 | TTR (0.53) | KDM4EALDH1A1SMN1; SMN2AKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204357-B1 | FLUORESCENT SYNTHETIC RETINOIDS | HIGH FORCE RES LIMITED (GB) | 2022-01-19 | — | — | EP | disclosed |
| US-10759762-B2 | Fluorescent synthetic retinoids | HIGH FORCE RESEARCH LIMITED (GB) | 2020-09-01 | — | — | US | disclosed |
| US-10059668-B2 | LSD1 inhibitors | Mirati Therapeutics, Inc. (US) | 2018-08-28 | — | — | US | disclosed |
| EP-3204357-A2 | FLUORESCENT SYNTHETIC RETINOIDS | High Force Research Limited (GB) | 2017-08-16 | — | — | EP | disclosed |
| US-20170217893-A1 | Fluorescent Synthetic Retinoids | HIGH FORCE RESEARCH LIMITED (GB) | 2017-08-03 | — | — | US | disclosed |
| WO-2017079476-A1 | LSD1 INHIBITORS | Mirati Therapeutics, Inc. (US) | 2017-05-11 | — | — | WO | disclosed |
| US-20170129857-A1 | LSD1 Inhibitors | Mirati Therapeutics, Inc. (US) | 2017-05-11 | — | — | US | disclosed |
| WO-2016055800-A2 | FLUORESCENT SYNTHETIC RETINOIDS | HIGH FORCE RESEARCH LIMITED (GB) | 2016-04-14 | — | — | WO | disclosed |
| US-7842825-B2 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activator | HOFFMANN-LA ROCHE INC. (US) | 2010-11-30 | — | — | US | disclosed |
| US-7700632-B2 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activator | HOFFMANN-LA ROCHE INC. (US) | 2010-04-20 | — | — | US | disclosed |
| US-20080255198-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATOR | CHU CHANG AN | 2008-10-16 | — | — | US | disclosed |
| US-20080108662-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATOR | CHU CHANG A | 2008-05-08 | — | — | US | disclosed |
| US-7355049-B2 | Biaryloxymethylarenecarboxylic acids as glycogen synthase activator | HOFFMANN-LA ROCHE INC. (US) | 2008-04-08 | — | — | US | disclosed |
| EP-1663936-B1 | BIARYLOXYMETHYLARENE-CARBOXYLIC ACIDS | HOFFMANN LA ROCHE (CH) | 2008-01-09 | — | — | EP | disclosed |
| US-6310217-B1 | ANTIINFLAMMATORY AND ANALGESIC AGENTS | MERCKLE GMBH (DE) | 2001-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170129857-A1 | LSD1 Inhibitors | KDM1B, KDM1A, KDM3A | KDM4E 14/4885ALDH1A1 364/4885PKM 914/4885 |
| US-10759762-B2 | Fluorescent synthetic retinoids | RARB, RXRB, RXRA | KDM4E 3264/4885ALDH1A1 383/4885PKM 4203/4885 |
| US-20080108662-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATOR | GYS2, PYGL, GYS1 | KDM4E 2525/4885ALDH1A1 499/4885PKM 432/4885 |
| US-20080255198-A1 | BIARYLOXYMETHYLARENECARBOXYLIC ACIDS AS GLYCOGEN SYNTHASE ACTIVATOR | GYS2, PYGL, GYS1 | KDM4E 2525/4885ALDH1A1 499/4885PKM 432/4885 |
| US-10059668-B2 | LSD1 inhibitors | KDM1B, KDM1A, KDM3A | KDM4E 14/4885ALDH1A1 364/4885PKM 914/4885 |
| US-20170217893-A1 | Fluorescent Synthetic Retinoids | RARB, RXRB, RXRA | KDM4E 3264/4885ALDH1A1 383/4885PKM 4203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.