Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3572314 | 0.79 | OPRM1 (0.38) | OPRM1OPRL1 | |
| SCHEMBL1046054 | 0.77 | OPRM1 (0.47) | OPRM1OPRL1 | |
| SCHEMBL22540282 | 0.74 | OPRM1 (0.45) | OPRM1OPRL1DDB1CRBNMEN1 | |
| SCHEMBL1303916 | 0.73 | OPRM1 (0.44) | OPRM1OPRL1DDB1CRBNMEN1 | |
| SCHEMBL208815 | 0.72 | OPRM1 (0.58) | OPRM1OPRL1DDB1CRBNMEN1 | |
| SCHEMBL10509430 | 0.69 | MMP2 (0.43) | OPRM1OPRL1MMP2MMP9MMP8 | |
| SCHEMBL3566012 | 0.69 | SIGMAR1 (0.44) | MMP2MMP9MMP8MMP13MEN1 | |
| SCHEMBL3571850 | 0.67 | MEN1 (0.39) | OPRM1OPRL1MMP2MMP9ALDH1A1 | |
| SCHEMBL3218308 | 0.67 | OPRM1 (0.41) | OPRM1OPRL1ALDH1A1MEN1CYP2C9 | |
| SCHEMBL3407753 | 0.66 | SLC6A2 (0.46) | OPRM1OPRL1DDB1CRBNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101622255-B | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH | 2013-12-11 | — | — | CN | disclosed |
| EP-2121689-B1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2013-07-31 | — | — | EP | disclosed |
| US-8404740-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-20100048554-A1 | Spirocyclic Cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2010-02-25 | — | — | US | disclosed |
| CN-101622255-A | Spirocyclic cyclohexane derivatives | GRUENENTHAL GMBH | 2010-01-06 | — | — | CN | disclosed |
| EP-2121689-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008101659-A1 | SPIROCYCLIC CYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048554-A1 | Spirocyclic Cyclohexane Compounds | OPRL1, OPRD1, OPRK1 | OPRM1 4/4885OPRL1 1/4885DDB1 3268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.