Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CCR9 | P51686 | 2/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 8/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584396 | 0.88 | C5AR1 (0.44) | SERPINE1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3577915 | 0.85 | F10 (0.38) | MEN1CYP1A2CYP2C19KMT2ACCR9 | |
| SCHEMBL3577656 | 0.84 | CNR1 (0.42) | SERPINE1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3579634 | 0.82 | SERPINE1 (0.40) | SERPINE1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3583634 | 0.81 | SERPINE1 (0.39) | SERPINE1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3581532 | 0.80 | RAB9A (0.41) | SERPINE1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3580741 | 0.80 | C5AR1 (0.40) | SERPINE1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3575555 | 0.80 | F10 (0.42) | SERPINE1CCR9F10KLKB1 | |
| SCHEMBL3581193 | 0.80 | CCR9 (0.39) | SERPINE1KDM4EALDH1A1GLAGAA | |
| SCHEMBL3580698 | 0.79 | C5AR1 (0.44) | KDM4EALDH1A1GLAGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |