Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | F7 | P08709 | 3/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 2/20 | 0.38 |
| ▸ | MC5R | P33032 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CCR9 | P51686 | 3/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584396 | 0.89 | C5AR1 (0.44) | C5AR1F10SERPINE1LPAR1LPAR5 | |
| SCHEMBL3579634 | 0.88 | SERPINE1 (0.40) | C5AR1SERPINE1KDM4EALDH1A1GLA | |
| SCHEMBL3583634 | 0.86 | SERPINE1 (0.39) | C5AR1SERPINE1KDM4EALDH1A1GLA | |
| SCHEMBL3575609 | 0.85 | LMNA (0.43) | C5AR1SERPINE1LPAR1LPAR5LMNA | |
| SCHEMBL3581193 | 0.85 | CCR9 (0.39) | C5AR1F10SERPINE1KDM4EALDH1A1 | |
| SCHEMBL3569982 | 0.84 | LPAR1 (0.41) | C5AR1SERPINE1LPAR1LPAR5ALDH1A1 | |
| SCHEMBL3587595 | 0.83 | C5AR1 (0.49) | C5AR1LPAR1LPAR5LMNAMEN1 | |
| SCHEMBL3581532 | 0.83 | RAB9A (0.41) | SERPINE1LPAR1LPAR5KDM4EALDH1A1 | |
| SCHEMBL3575555 | 0.81 | F10 (0.42) | F10SERPINE1CCR9 | |
| SCHEMBL3575452 | 0.81 | KMT2A (0.42) | C5AR1ALDH1A1GLANPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |