Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 5/20 | 0.46 |
| ▸ | INSR | P06213 | 3/20 | 0.46 |
| ▸ | ARG1 | P05089 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 5/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579366 | 0.82 | CDK1 (0.44) | CDK1CCNB1CCNB2CCNB3TP53 | |
| SCHEMBL3581003 | 0.78 | P2RX3 (0.39) | CDK1CCNB1CCNB2CCNB3ALOX15 | |
| SCHEMBL2913009 | 0.71 | CDK2 (0.53) | CDK1CCNB1CCNB2CCNB3TP53 | |
| SCHEMBL3574162 | 0.70 | NTRK1 (0.43) | CDK1MAPK1CCNE1CDK2FGFR1 | |
| SCHEMBL3572417 | 0.70 | NTRK1 (0.43) | CDK1MAPK1CCNE1CDK2FGFR1 | |
| SCHEMBL7255577 | 0.66 | — | — | |
| SCHEMBL23477029 | 0.65 | ALDH1A1 (0.37) | ALDH1A1 | |
| SCHEMBL3242569 | 0.64 | CCNB2 (0.70) | CDK1CCNB1CCNB2CCNB3ALOX15 | |
| SCHEMBL3581000 | 0.64 | — | — | |
| SCHEMBL16146530 | 0.63 | ALPL (0.54) | ALPLALPGPLAAIGF1RINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745450-B2 | Pyrazolo[4,3-d]pyrimidines, processes for their preparation and methods for therapy | INSTITUTE OF EXPERIMENTAL BOTANY (CZ) | 2010-06-29 | — | — | US | disclosed |
| US-20050080097-A1 | Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy | USTAV EXPERIMENTALNI BOTANIKY AV CR (INSTITUTE OF EXPERIMENTAL BOTANY ACADEMY OF | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080097-A1 | Pyrazolo[4,3-D]pyrimidines, processes for their preparation and methods for therapy | CBR3, DHFR, AKR1C3 | ALPL 4533/4885ALPG 4385/4885PLAA 4824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.