SCHEMBL357230

SCHEMBL357230

CN(C)C(=O)c1ccc(N)c(Cl)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.49
POLB P06746 1/20 0.49
HPGD P15428 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HSP90AA1 P07900 2/20 0.44
HSP90AB1 P08238 1/20 0.44
TSHR P16473 4/20 0.43
CYP3A4 P08684 3/20 0.43
THRB P10828 1/20 0.43
ALOX15 P16050 1/20 0.43
CASP1 P29466 1/20 0.43
RECQL P46063 1/20 0.43
HSD17B10 Q99714 1/20 0.43
SLC6A4 P31645 5/20 0.41
SLC6A2 P23975 4/20 0.41
SLC6A3 Q01959 4/20 0.41
CYP2D6 P10635 3/20 0.41
MAPK1 P28482 2/20 0.41
GAA P10253 1/20 0.41
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10318165 0.85 KDM4E (0.50) ALDH1A1HPGDSMN1; SMN2TSHRHSD17B10
SCHEMBL17555209 0.83 HSP90AA1 (0.50) ALDH1A1POLBHPGDSMN1; SMN2HSP90AA1
SCHEMBL6865515 0.82 MAPT (0.48) ALDH1A1HPGDSMN1; SMN2HSP90AA1CYP3A4
SCHEMBL11700283 0.81 HSP90AA1 (0.69) ALDH1A1POLBHPGDSMN1; SMN2HSP90AA1
SCHEMBL12010059 0.80 ALDH1A1 (0.46) ALDH1A1POLBHPGDSMN1; SMN2HSP90AA1
SCHEMBL1853218 0.79 ALDH1A1 (0.46) ALDH1A1HPGDSMN1; SMN2HSP90AA1CYP3A4
SCHEMBL12599208 0.79 NPC1 (0.49) ALDH1A1HPGDSMN1; SMN2HSP90AA1HSP90AB1
SCHEMBL13205433 0.79 PDK2 (0.47) ALDH1A1POLBHPGDSMN1; SMN2HSP90AA1
SCHEMBL29447970 0.79 PDK2 (0.47) ALDH1A1POLBHPGDSMN1; SMN2HSP90AA1
SCHEMBL355700 0.79 HSP90AA1 (0.67) ALDH1A1HPGDSMN1; SMN2HSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11897877-B2 Inhibitor compounds CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-02-13 US disclosed
US-20220402912-A1 INHIBITOR COMPOUNDS INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) (GB) 2022-12-22 US disclosed
US-20220402912-A1 INHIBITOR COMPOUNDS INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) (GB) 2022-12-22 US disclosed
US-11046688-B2 Inhibitor compounds CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2021-06-29 US disclosed
US-11046688-B2 Inhibitor compounds CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2021-06-29 US disclosed
US-20200165241-A1 INHIBITOR COMPOUNDS INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) (GB) 2020-05-28 US disclosed
US-20200165241-A1 INHIBITOR COMPOUNDS INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE) (GB) 2020-05-28 US disclosed
US-10479788-B2 Compounds that inhibit MPS1 kinase CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2019-11-19 US disclosed
US-10479788-B2 Compounds that inhibit MPS1 kinase CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2019-11-19 US disclosed
EP-3293183-B1 INHIBITOR COMPOUNDS CANCER RESEARCH TECH LTD (GB) 2019-07-24 EP disclosed
EP-2276767-A1 BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE Genentech, Inc. (US) 2011-01-26 EP disclosed
EP-2144902-A1 [6,6]AND [6,7]-BICYCLIC GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS Bristol-Myers Squibb Company (US) 2010-01-20 EP disclosed
WO-2009123971-A1 BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2009-10-08 WO disclosed
WO-2009123971-A1 BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2009-10-08 WO disclosed
US-20090247567-A1 BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2009-10-01 US disclosed
US-20090247567-A1 BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2009-10-01 US disclosed
US-20090247567-A1 BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2009-10-01 US disclosed
US-20080293690-A1 [6,6] AND [6,7]-BICYCLIC GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY 2008-11-27 US disclosed
WO-2008137435-A1 [6,6] AND [6,7]-BICYCLIC GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS BRISTOL-MYERS SQUIBB COMPANY (US) 2008-11-13 WO disclosed
US-4031073-A Monoazo pigments containing barbituric acid or thio- or imino-derivatives thereof CIBA-GEIGY CORPORATION (US) 1977-06-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10479788-B2 Compounds that inhibit MPS1 kinase BUB1B, BUB1, CDK1 ALDH1A1 4006/4885POLB 1349/4885HPGD 4473/4885
US-20220402912-A1 INHIBITOR COMPOUNDS BUB1B, BUB1, CDK1 ALDH1A1 3742/4885POLB 1230/4885HPGD 4376/4885
US-11046688-B2 Inhibitor compounds BUB1B, BUB1, CDK1 ALDH1A1 3742/4885POLB 1230/4885HPGD 4376/4885
US-11897877-B2 Inhibitor compounds BUB1B, BUB1, CDK1 ALDH1A1 3742/4885POLB 1230/4885HPGD 4376/4885
US-20080293690-A1 [6,6] AND [6,7]-BICYCLIC GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS GPR119, GPR6, GPR139 ALDH1A1 2019/4885POLB 4798/4885HPGD 1487/4885
US-20200165241-A1 INHIBITOR COMPOUNDS BUB1B, BUB1, CDK1 ALDH1A1 3742/4885POLB 1230/4885HPGD 4376/4885
US-20090247567-A1 BENZOPYRAN AND BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE PIK3CA, BMX, PIK3CD ALDH1A1 4004/4885POLB 793/4885HPGD 669/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.