Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6045553 | 0.72 | OPRL1 (0.45) | CYP1A2CYP2C9CYP2C19ALDH1A1TSHR | |
| SCHEMBL21399642 | 0.69 | OPRM1 (0.37) | OPRM1OPRL1SMN1; SMN2 | |
| SCHEMBL3573052 | 0.68 | ALDH1A1 (0.39) | SLC6A4SLC6A3ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL12981782 | 0.67 | OPRM1 (0.38) | KDM4EOPRM1OPRL1MEN1KMT2A | |
| SCHEMBL3570981 | 0.67 | CSNK1E (0.40) | SLC6A4SLC6A3ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL10780105 | 0.65 | CNR1 (0.49) | ALDH1A1OPRM1OPRL1MEN1KMT2A | |
| SCHEMBL3406992 | 0.65 | CHRM2 (0.46) | SLC6A4SLC6A3ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL31147497 | 0.65 | MAOA (0.41) | SLC6A4SLC6A3ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL8790549 | 0.65 | CYP3A4 (0.36) | ALDH1A1TSHRL3MBTL1KDM4EHPGD | |
| SCHEMBL27874183 | 0.65 | OPRM1 (0.53) | SLC6A4SLC6A3OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404740-B2 | Spirocyclic cyclohexane compounds | GRUENENTHAL GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-20100048554-A1 | Spirocyclic Cyclohexane Compounds | GRUENENTHAL GMBH (DE) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048554-A1 | Spirocyclic Cyclohexane Compounds | OPRL1, OPRD1, OPRK1 | SLC6A4 3734/4885SLC6A3 3074/4885CYP1A2 537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.