Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.59 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14275545 | 0.91 | SMN1; SMN2 (0.64) | GAAALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL9001940 | 0.85 | GAA (0.70) | GAAALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL11293119 | 0.84 | GAA (0.85) | GAAALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL31668470 | 0.84 | GAA (0.68) | GAAALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL15070498 | 0.84 | GAA (0.68) | GAAALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL7301613 | 0.83 | ALDH1A1 (0.74) | GAAALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL2666138 | 0.81 | GAA (1.00) | GAAALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL23777007 | 0.80 | GAA (0.62) | GAAALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL14145255 | 0.80 | L3MBTL1 (0.72) | GAAALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL14019248 | 0.80 | GAA (0.62) | GAAALDH1A1MAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2592933-B1 | MIF INHIBITORS AND THEIR USES | GAWECO ANDERSON (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2592933-B1 | MIF INHIBITORS AND THEIR USES | GAWECO ANDERSON (US) | 2017-04-05 | — | — | EP | disclosed |
| US-9050334-B2 | MIF inhibitors and their uses | INNOV88 LLC (US) | 2015-06-09 | — | — | US | disclosed |
| US-9050334-B2 | MIF inhibitors and their uses | INNOV88 LLC (US) | 2015-06-09 | — | — | US | disclosed |
| US-9050334-B2 | MIF inhibitors and their uses | INNOV88 LLC (US) | 2015-06-09 | — | — | US | disclosed |
| EP-2592933-A1 | MIF INHIBITORS AND THEIR USES | Gaweco, Anderson (US) | 2013-05-22 | — | — | EP | disclosed |
| US-20120035150-A1 | MIF INHIBITORS AND THEIR USES | INNOV88 LLC | 2012-02-09 | — | — | US | disclosed |
| US-20120035150-A1 | MIF INHIBITORS AND THEIR USES | INNOV88 LLC | 2012-02-09 | — | — | US | disclosed |
| US-20120035150-A1 | MIF INHIBITORS AND THEIR USES | INNOV88 LLC | 2012-02-09 | — | — | US | disclosed |
| WO-2012009649-A1 | MIF INHIBITORS AND THEIR USES | GAWECO ANDERSON (US) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012009649-A1 | MIF INHIBITORS AND THEIR USES | GAWECO ANDERSON (US) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035150-A1 | MIF INHIBITORS AND THEIR USES | MIF, SERPINB1, HMGB2 | GAA 1974/4885ALDH1A1 790/4885MAPT 3074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.