Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ESRRG | P62508 | 4/20 | 0.37 |
| ▸ | ESRRB | O95718 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3578799 | 0.93 | TP53 (0.39) | C5AR1NR1H4PPARGTP53MAPT | |
| SCHEMBL3575452 | 0.91 | KMT2A (0.42) | C5AR1NR1H4PPARGESRRGESRRB | |
| SCHEMBL3583634 | 0.91 | SERPINE1 (0.39) | C5AR1NR1H4TP53MAPTESRRG | |
| SCHEMBL3587595 | 0.88 | C5AR1 (0.49) | C5AR1NR1H4ESRRGESRRBOPRM1 | |
| SCHEMBL3575602 | 0.86 | LPAR1 (0.38) | NR1H4PPARGTP53MAPTESRRG | |
| SCHEMBL3581107 | 0.84 | RAB9A (0.37) | C5AR1NR1H4TP53MAPTESRRG | |
| SCHEMBL3579507 | 0.84 | HDAC8 (0.41) | NR1H4PPARGKMT2A | |
| SCHEMBL3579634 | 0.83 | SERPINE1 (0.40) | C5AR1NR1H4TP53MAPTESRRG | |
| SCHEMBL3574429 | 0.81 | KDM4C (0.39) | NR1H4MAPTESRRGESRRBOPRM1 | |
| SCHEMBL3573203 | 0.81 | RAF1 (0.40) | C5AR1NR1H4TP53MAPTESRRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |