Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | ESRRG | P62508 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | ESRRB | O95718 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584396 | 0.89 | C5AR1 (0.44) | C5AR1CNR1ESRRGKMT2AMEN1 | |
| SCHEMBL3575452 | 0.89 | KMT2A (0.42) | C5AR1ESRRGKMT2AMEN1NR1H4 | |
| SCHEMBL3570707 | 0.88 | C5AR1 (0.39) | C5AR1ESRRGKMT2ALPAR1LPAR5 | |
| SCHEMBL3578799 | 0.86 | TP53 (0.39) | C5AR1ESRRGKMT2ARCE1LPAR1 | |
| SCHEMBL3574076 | 0.84 | HDAC1 (0.52) | LPAR1LPAR5HDAC1HDAC6 | |
| SCHEMBL3581107 | 0.83 | RAB9A (0.37) | C5AR1ESRRGKMT2ANR1H4ESRRB | |
| SCHEMBL3580741 | 0.83 | C5AR1 (0.40) | C5AR1KMT2AMEN1LPAR1LPAR5 | |
| SCHEMBL3579507 | 0.83 | HDAC8 (0.41) | KMT2AMEN1NR1H4PTGESHDAC1 | |
| SCHEMBL3579634 | 0.82 | SERPINE1 (0.40) | C5AR1ESRRGKMT2AMEN1CYP1A2 | |
| SCHEMBL3575602 | 0.81 | LPAR1 (0.38) | ESRRGKMT2ALPAR1LPAR5NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |