Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 9/20 | 0.45 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576336 | 0.86 | PARP1 (0.62) | PARP1AURKAAURKB | |
| SCHEMBL3574583 | 0.83 | AURKB (0.49) | PARP1AURKAAURKBCHEK2 | |
| SCHEMBL3577227 | 0.83 | AURKA (0.53) | PARP1AURKAAURKBCHEK2ALDH1A1 | |
| SCHEMBL3587289 | 0.81 | AURKA (0.56) | PARP1AURKAAURKBCHEK2ALDH1A1 | |
| SCHEMBL3579920 | 0.81 | AURKA (0.49) | PARP1AURKAAURKBCHEK2 | |
| SCHEMBL3582849 | 0.81 | AURKB (0.58) | PARP1AURKAAURKBCHEK2 | |
| SCHEMBL3582854 | 0.79 | AURKB (0.70) | PARP1AURKAAURKBCHEK2 | |
| SCHEMBL3582373 | 0.78 | PARP1 (0.49) | PARP1ATRAURKAAURKBCHEK2 | |
| SCHEMBL3576982 | 0.78 | AURKA (0.52) | PARP1AURKAAURKBCHEK2 | |
| SCHEMBL3582282 | 0.78 | AURKB (0.61) | PARP1AURKAAURKBCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |