SCHEMBL357814

SCHEMBL357814

C=CCc1cccc2c1CCC2O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 1/20 0.42
GABRB2 P47870 1/20 0.42
KMT2A Q03164 1/20 0.38
DRD2 P14416 9/20 0.37
HTR1A P08908 8/20 0.37
KDM4E B2RXH2 1/20 0.34
LMNA P02545 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
GAA P10253 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
HPGD P15428 1/20 0.34
ALOX15 P16050 1/20 0.34
ALOX12 P18054 1/20 0.34
CYP2C19 P33261 1/20 0.34
HTT P42858 1/20 0.34
POLL Q9UGP5 1/20 0.34
AKR1B1 P15121 1/20 0.34
NR3C2 P08235 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9455921 1.00 GABRA1 (0.42) GABRA1GABRB2KMT2ADRD2HTR1A
SCHEMBL6752027 0.80 HTR1A (0.40) GABRA1GABRB2HTR1AKDM4ELMNA
SCHEMBL1508764 0.78 POLL (0.43) GABRA1GABRB2KMT2APOLLADRA1A
SCHEMBL1508337 0.78 POLL (0.43) GABRA1GABRB2KMT2APOLLADRA1A
SCHEMBL17571276 0.78 POLL (0.43) GABRA1GABRB2KMT2APOLLADRA1A
SCHEMBL9455939 0.76 KMT2A (0.37) KMT2APOLLNR3C2ADRA1A
SCHEMBL9456041 0.76 KMT2A (0.37) KMT2ADRD2POLLNR3C2ADRA1A
SCHEMBL9456077 0.75 HTR2A (0.43) KMT2ADRD2HTR1APOLLADRA1A
SCHEMBL9506611 0.74 TBXA2R (0.42) KMT2AKDM4ECYP1A2CYP2C9HPGD
SCHEMBL28950294 0.74 KMT2A (0.38) KMT2APOLLNR3C2ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1792889-B1 Process for the preparation of carboxylic acid esters SUMITOMO CHEMICAL CO (JP) 2015-03-04 EP disclosed
EP-2418197-B1 PROCESS FOR PRODUCING 3-(2-CYANO-1-PROPENYL)-2,2- DIMETHYLCYCLOPROPANECARBOXYLIC ACID OR SALT THEREOF SUMITOMO CHEMICAL CO (JP) 2014-05-07 EP disclosed
EP-1547995-B1 Process for the preparation of carboxylic acid esters SUMITOMO CHEMICAL CO (JP) 2014-05-07 EP disclosed
US-8461370-B2 Process for producing 3-(2-cyano-1-propenyl)-2,2- dimethylcyclopropanecarboxylic acid or salt thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-06-11 US disclosed
EP-2537828-A1 METHOD FOR PRODUCING CYANOALKENYLCYCLOPROPANECARBOXYLIC ACID SALT Sumitomo Chemical Company, Limited (JP) 2012-12-26 EP disclosed
US-20120310003-A1 METHOD FOR PRODUCING CYANOALKENYLCYCLOPROPANECARBOXYLIC ACID SALT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-12-06 US disclosed
EP-2418197-A1 PROCESS FOR PRODUCING 3-(2-CYANO-1-PROPENYL)-2,2- DIMETHYLCYCLOPROPANECARBOXYLIC ACID OR SALT THEREOF Sumitomo Chemical Company, Limited (JP) 2012-02-15 EP disclosed
US-20120016150-A1 Process for Producing 3-(2-Cyano-1-propenyl)-2,2- Dimethylcyclopropanecarboxylic Acid or Salt Thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-01-19 US disclosed
US-7741511-B2 Process for the preparation of carboxylic acid esters SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-22 US disclosed
US-7399873-B2 Process for the preparation of carboxylic acid esters SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-07-15 US disclosed
US-20020151741-A1 Process for producing cyclopropanecarboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-10-17 US disclosed
US-6441220-B1 ESTERIFICATION WITH ALCOHOL IN PRESENCE OF BASIC CATALYSTS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-08-27 US disclosed
EP-1227077-A2 Process for producing cyclopropanecarboxylates Sumitomo Chemical Co.,Ltd. (JP) 2002-07-31 EP disclosed
EP-1203760-A1 Method for producing cyclopropanecarboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2002-05-08 EP disclosed
EP-1061065-A2 Methods for producing cyclopropane carboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-12-20 EP disclosed
EP-0992479-A1 Method for producing cyclopropanecarboxylates SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2000-04-12 EP disclosed
EP-0357742-B1 NEW PYRETHRINOID ESTERS CARRYING AN INDANYL RING, PREPARATION METHOD AND APPLICATION AS PESTICIDES ROUSSEL-UCLAF (FR) 1993-06-09 EP disclosed
US-5180741-A Insecticides ROUSSEL UCLAF (FR) 1993-01-19 US disclosed
EP-0357742-A1 NEW PYRETHRINOID ESTERS CARRYING AN INDANYL RING, PREPARATION METHOD AND APPLICATION AS PESTICIDES. ROUSSEL UCLAF (FR) 1990-03-14 EP disclosed
WO-1989008096-A1 NEW PYRETHRINOID ESTERS CARRYING AN INDANYL RING, PREPARATION METHOD AND APPLICATION AS PESTICIDES ROUSSEL-UCLAF (FR) 1989-09-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020151741-A1 Process for producing cyclopropanecarboxylates CYC1, CYP21A2, CYP2A6 GABRA1 3115/4885GABRB2 2499/4885KMT2A 4179/4885
US-20120310003-A1 METHOD FOR PRODUCING CYANOALKENYLCYCLOPROPANECARBOXYLIC ACID SALT MCCC2, AOC2, DDC GABRA1 1341/4885GABRB2 1179/4885KMT2A 1178/4885
US-20120016150-A1 Process for Producing 3-(2-Cyano-1-propenyl)-2,2- Dimethylcyclopropanecarboxylic Acid or Salt Thereof CPS1, PCCA, PKD1 GABRA1 2104/4885GABRB2 2327/4885KMT2A 1950/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.