Sugi Predict

Sugi Predict / Compounds / Pyrazole

Pyrazole

Pyrazole

SCHEMBL357858

NC(=O)c1ncccn1.c1cn[nH]c1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ P2RX7 Q99572 1/20 0.39
▸ CSNK1A1 P48729 1/20 0.33
▸ TYRO3 Q06418 1/20 0.33
▸ DYRK1B Q9Y463 1/20 0.33
▸ PARP1 P09874 1/20 0.33
▸ PARP10 Q53GL7 1/20 0.32
▸ RAB9A P51151 1/20 0.31
▸ MKNK1 Q9BUB5 2/20 0.31
▸ MKNK2 Q9HBH9 2/20 0.31
▸ KDM4E B2RXH2 1/20 0.31
▸ CTNNB1 P35222 1/20 0.31
▸ WNT3A P56704 1/20 0.31
▸ ADORA3 P0DMS8 1/20 0.31
▸ TSHR P16473 1/20 0.31
▸ MC4R P32245 1/20 0.31
▸ ADRA1A P35348 1/20 0.31
▸ MC3R P41968 1/20 0.31
▸ LIMK1 P53667 2/20 0.30
▸ IKBKB O14920 1/20 0.30
▸ CHUK O15111 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pyrazole SCHEMBL358845 0.82 NAPRT (0.36) P2RX7KDM4ECTNNB1WNT3ATSHR
Pyrazole SCHEMBL1129000 0.81 — —
SCHEMBL158178 0.81 — —
Pyrazole SCHEMBL28727019 0.79 — —
Pyrazole SCHEMBL440249 0.79 — —
Pyrazole SCHEMBL2511053 0.79 CES2 (0.48) RAB9A
Hydrochloric Acid SCHEMBL25337662 0.79 P2RX7 (0.52) P2RX7PARP1PARP10MKNK1MKNK2
Ammonia Solution, Strong SCHEMBL17104818 0.79 P2RX7 (0.52) P2RX7PARP1PARP10MKNK1MKNK2
Hydrochloric Acid SCHEMBL27440453 0.79 P2RX7 (0.52) P2RX7PARP1PARP10MKNK1MKNK2
SCHEMBL27431959 0.79 P2RX7 (0.52) P2RX7PARP1PARP10MKNK1MKNK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115551859-B Aza condensed ring amide compound and application thereof 石药集团中奇制药技术（石家庄）有限公司 2024-08-27 — — CN disclosed
CN-106232794-B Fabric care compositions comprising polyurethane, polyurea and/or polyurethaneurea polymers 宝洁公司 2023-04-21 — — CN disclosed
CN-115551859-A Aza condensed ring amide compound and application thereof 石药集团中奇制药技术（石家庄）有限公司 2022-12-30 — — CN disclosed
CN-107743421-B Apparatus and method for applying a composition to a surface 宝洁公司 2021-02-09 — — CN disclosed
CN-106164235-B Cleaning compositions comprising polyetheramines 宝洁公司 2020-01-31 — — CN disclosed
CN-110003219-A Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator 弗·哈夫曼-拉罗切有限公司 2019-07-12 — — CN disclosed
CN-105367577-B Pyrazolo [1,5A] pyrimidine and thieno [3,2B] pyrimidine derivatives as IRAK4 regulator 弗·哈夫曼-拉罗切有限公司 2019-04-23 — — CN disclosed
US-20190091195-A1 USE OF DIANHYDROGALACTITOL AND DERIVATIVES THEREOF IN THE TREATMENT OF GLIOBLASTOMA, LUNG CANCER, AND OVARIAN CANCER DEL MAR PHARMACEUTICALS (CA) 2019-03-28 — — US disclosed
US-20180298026-A1 Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators HOFFMANN-LA ROCHE INC. 2018-10-18 — — US disclosed
US-10023589-B2 Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators HOFFMANN-LA ROCHE INC. (US) 2018-07-17 — — US disclosed
CN-102612553-A High-efficiency capsules comprising benefit agents PROCTER & GAMBLE 2012-07-25 — — CN disclosed
CN-102575198-A A laundry detergent composition comprising a highly water-soluble carboxymethyl cellulose particle PROCTER & GAMBLE 2012-07-11 — — CN disclosed
US-20120015962-A1 PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS ARORA NIDHI (US) 2012-01-19 — — US disclosed
WO-2012007375-A1 PYRAZOLO [1, 5A] PYRIMIDINE AND THIENO [3, 2B] PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS F. HOFFMANN-LA ROCHE AG (CH) 2012-01-19 — — WO disclosed
CN-102112602-A Detergent compositions comprising lipase PROCTER & GAMBLE 2011-06-29 — — CN disclosed
CN-101960007-A Detergent composition comprising lipase PROCTER & GAMBLE 2011-01-26 — — CN disclosed
CN-101910392-A Enzyme and fabric hueing agent containing compositions PROCTER & GAMBLE 2010-12-08 — — CN disclosed
CN-101490230-A Detergent compositions PROCTER & GAMBLE (US) 2009-07-22 — — CN disclosed
CN-101374934-A Enzyme and fabric hueing agent containing compositions PROCTER & GAMBLE (US) 2009-02-25 — — CN disclosed
CN-101370920-A Detergent compositions PROCTER & GAMBLE (US) 2009-02-18 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10023589-B2 Pyrazolo[1,5a]pyrimidine derivatives as IRAK4 modulators IRAK4, IRAK1, IRAK2 P2RX7 254/4885CSNK1A1 186/4885TYRO3 516/4885
US-20190091195-A1 USE OF DIANHYDROGALACTITOL AND DERIVATIVES THEREOF IN THE TREATMENT OF GLIOBLASTOMA, LUNG CANCER, AND OVARIAN CANCER DDOST, DCLRE1A, OGG1 P2RX7 2735/4885CSNK1A1 4559/4885TYRO3 4756/4885
US-20120015962-A1 PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS IRAK4, IRAK1, IRAK2 P2RX7 254/4885CSNK1A1 186/4885TYRO3 516/4885
US-20180298026-A1 Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators IRAK4, IRAK1, IRAK2 P2RX7 254/4885CSNK1A1 186/4885TYRO3 516/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.