Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Halazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.64 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.64 |
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.64 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.64 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.64 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.64 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.64 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.64 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.64 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.64 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.64 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.64 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.64 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.64 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.64 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 4/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Halazepam SCHEMBL29375979 | 1.00 | OPRK1 (1.00) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Halazepam SCHEMBL28086644 | 0.92 | OPRK1 (0.85) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Halazepam SCHEMBL28086105 | 0.88 | OPRK1 (0.77) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL5379874 | 0.87 | OPRK1 (0.77) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL13352364 | 0.86 | OPRK1 (0.76) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL3249926 | 0.86 | NR1I2 (0.74) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Halazepam SCHEMBL17396210 | 0.85 | OPRK1 (0.72) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL5355886 | 0.85 | OPRK1 (0.73) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL3579580 | 0.85 | OPRK1 (0.73) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL5349082 | 0.85 | TP53 (0.84) | OPRK1NR1I2ADORA3OPRM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10244 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026090360-A1 | FUSED PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC. (US) | 2026-04-30 | — | — | WO | claimed |
| US-20260108529-A1 | FUSED AMINO PYRIMIDINE COMPOUNDS FOR TREATMENT OF TINNITUS, ACUTE SENSORINEURAL HEARING LOSS, AGE-RELATED HEARING LOSS, AND MENIERE'S DISEASE | OVID THERAPEUTICS INC (US) | 2026-04-23 | — | — | US | claimed |
| US-20260076953-A1 | METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2026-03-19 | — | — | US | claimed |
| US-20250375421-A1 | METHODS OF USING DMT | SHULMAN WILLIAM (US) | 2025-12-11 | — | — | US | claimed |
| US-12396981-B2 | Methods of using DMT | SHULMAN WILLIAM (US) | 2025-08-26 | — | — | US | claimed |
| US-20250205146-A1 | GRAPHENE-BASED DRUG DELIVERY DEVICE FOR MUCOSAL AND TRANSMUCOSAL ADMINISTRATION | SISSA - SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI (IT) | 2025-06-26 | — | — | US | claimed |
| WO-2025126159-A1 | A METHOD FOR TREATING A NEUROLOGICAL DISEASE IN A RECREATIONAL DRUG USER | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2025-06-19 | — | — | WO | claimed |
| US-20250179064-A1 | BENZOQUINOLONE INHIBITORS OF VMAT2 | AUSPEX PHARMACEUTICALS LLC | 2025-06-05 | — | — | US | claimed |
| WO-2025111482-A1 | COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS | BEXSON BIOMEDICAL, INC. (US) | 2025-05-30 | — | — | WO | claimed |
| US-20250120962-A1 | NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ATTENTION DEFICIT DISORDER AND 22Q SYNDROME | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2025-04-17 | — | — | US | claimed |
| WO-1992020328-A2 | IMPROVEMENTS IN BENZODIAZEPINE TREATMENT BY CHOLINESTERASE INHIBITORS | SNORRASON ERNIR (IS) | 1992-11-26 | — | — | WO | claimed |
| EP-0515301-A2 | Improvements in benzodiazepine treatment by cholinesterterase inhibitors | Snorrason, Ernir (IS) | 1992-11-25 | — | — | EP | claimed |
| EP-0328282-B1 | PHARMACEUTICAL | ICI AMERICAS INC. (US) | 1992-08-19 | — | — | EP | claimed |
| EP-0428272-A2 | Trifluorobenzodiazepine compounds for use in therapy by intraoral administration | Ellinwood, Everett Hews (US) | 1991-05-22 | — | — | EP | claimed |
| US-4925844-A | ADMINISTERING 4-AMINO-8-PHENYL-N-PROPYL-3-CINNOLINECARBOXAMIDE | ICI AMERICAS INC. (US) | 1990-05-15 | — | — | US | claimed |
| EP-0328282-A2 | Pharmaceutical | ICI AMERICAS INC. (US) | 1989-08-16 | — | — | EP | claimed |
| EP-0098113-B1 | A COMBINATION OF BETA-ADRENOCEPTOR ANTAGONISTS AND ANXIOLYTIC AGENTS | AYERST, MCKENNA AND HARRISON INC. (CA) | 1986-09-03 | — | — | EP | claimed |
| US-4595684-A | Method of suppressing benzodiazepine induced sedation with 2-(p-methoxypenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one or a salt thereof | CIBA-GEIGY CORPORATION (US) | 1986-06-17 | — | — | US | claimed |
| EP-0098113-A1 | A combination of beta-adrenoceptor antagonists and anxiolytic agents | AYERST, MCKENNA AND HARRISON INC. (CA) | 1984-01-11 | — | — | EP | claimed |
| US-4155904-A | Process for the preparation of 1,4-benzo-diazepines and 1,4-benzodiazepinones | SCHERING CORPORATION (US) | 1979-05-22 | — | — | US | claimed |