Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | CCR9 | P51686 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.31 |
| ▸ | CTSB | P07858 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3582314 | 0.89 | CCR9 (0.38) | TRPM8CCR9KDM4CLMNAHTT | |
| SCHEMBL3574298 | 0.81 | KDM4E (0.36) | TRPM8CCR9LMNAMAPTTDP1 | |
| SCHEMBL3584236 | 0.81 | HCRTR1 (0.42) | — | |
| SCHEMBL3576379 | 0.80 | HSP90AA1 (0.46) | CCR9HSP90AA1HDAC3HDAC8HDAC6 | |
| SCHEMBL3570653 | 0.79 | CNR1 (0.39) | TRPM8LMNATDP1HDAC8HDAC6 | |
| SCHEMBL3582723 | 0.79 | HCRTR1 (0.37) | TRPM8CCR9MAPTF10 | |
| SCHEMBL3576692 | 0.78 | ESRRG (0.37) | TRPM8CCR9HSP90AA1F10 | |
| SCHEMBL3577915 | 0.77 | F10 (0.38) | CCR9F10 | |
| SCHEMBL3581175 | 0.76 | ESRRG (0.36) | CCR9MAPTHSP90AA1HDAC3HDAC8 | |
| SCHEMBL3576392 | 0.75 | HCRTR1 (0.38) | TRPM8CCR9LMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |