Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580336 | 0.98 | MAPT (0.42) | TRPV1TRPA1KCNH2TRPM8MAPT | |
| SCHEMBL3578401 | 0.86 | CNR2 (0.39) | TRPV1OPRM1OPRD1HCRTR1HCRTR2 | |
| SCHEMBL3578400 | 0.86 | CNR2 (0.39) | TRPV1OPRM1OPRD1HCRTR1HCRTR2 | |
| SCHEMBL3573203 | 0.85 | RAF1 (0.40) | MAPTOPRM1OPRD1HCRTR1HCRTR2 | |
| SCHEMBL3582883 | 0.84 | RAF1 (0.40) | MAPTOPRM1OPRD1HCRTR1HCRTR2 | |
| SCHEMBL3580658 | 0.82 | RAF1 (0.39) | OPRM1OPRD1HCRTR1HCRTR2RAF1 | |
| SCHEMBL3575452 | 0.82 | KMT2A (0.42) | OPRM1OPRD1RAF1MAP2K1MEN1 | |
| SCHEMBL3583661 | 0.80 | BTK (0.41) | TRPV1TRPA1KCNH2TRPM8OPRM1 | |
| SCHEMBL3581747 | 0.79 | CCR9 (0.39) | MAPTOPRM1OPRD1HSD17B10RAF1 | |
| SCHEMBL3574429 | 0.78 | KDM4C (0.39) | TRPV1MAPTOPRM1OPRD1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |