Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | ESRRB | O95718 | 1/20 | 0.34 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580658 | 0.89 | RAF1 (0.39) | RAF1MAP2K1OPRM1OPRD1MEN1 | |
| SCHEMBL3580209 | 0.88 | MCHR1 (0.40) | BTKCRHR1HDAC3HDAC8HDAC6 | |
| SCHEMBL3576972 | 0.87 | BTK (0.36) | BTKCRHR1HDAC3HDAC8HDAC6 | |
| SCHEMBL3581747 | 0.85 | CCR9 (0.39) | RAF1MAP2K1OPRM1OPRD1MEN1 | |
| SCHEMBL3573203 | 0.84 | RAF1 (0.40) | RAF1MAP2K1OPRM1OPRD1MEN1 | |
| SCHEMBL3582883 | 0.83 | RAF1 (0.40) | RAF1MAP2K1OPRM1OPRD1MEN1 | |
| SCHEMBL3572867 | 0.82 | MEN1 (0.38) | HDAC3HDAC8HDAC6OPRM1OPRD1 | |
| SCHEMBL3575452 | 0.81 | KMT2A (0.42) | RAF1MAP2K1OPRM1OPRD1MEN1 | |
| SCHEMBL3581464 | 0.80 | TRPV1 (0.41) | RAF1MAP2K1OPRM1OPRD1MEN1 | |
| SCHEMBL3580336 | 0.80 | MAPT (0.42) | RAF1MAP2K1OPRM1OPRD1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |