Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ESRRB | O95718 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580658 | 0.89 | RAF1 (0.39) | KDRRAF1MAP2K1ESRRBESRRG | |
| SCHEMBL3570650 | 0.88 | CCR9 (0.41) | CCR9ESRRBESRRGNR1H4VNN1 | |
| SCHEMBL3583661 | 0.85 | BTK (0.41) | RAF1MAP2K1ESRRBESRRGMEN1 | |
| SCHEMBL3573203 | 0.85 | RAF1 (0.40) | RAF1MAP2K1ESRRBESRRGMEN1 | |
| SCHEMBL3582883 | 0.84 | RAF1 (0.40) | RAF1MAP2K1ESRRBESRRGMEN1 | |
| SCHEMBL3575452 | 0.82 | KMT2A (0.42) | RAF1MAP2K1ALDH1A1ESRRBESRRG | |
| SCHEMBL3580336 | 0.79 | MAPT (0.42) | RAF1MAP2K1HSD17B10MEN1KMT2A | |
| SCHEMBL3581464 | 0.79 | TRPV1 (0.41) | RAF1MAP2K1HSD17B10MEN1KMT2A | |
| SCHEMBL3585932 | 0.79 | CCR9 (0.36) | CCR9ESRRBESRRGNR1H4OPRM1 | |
| SCHEMBL3576645 | 0.78 | HSP90AA1 (0.37) | ESRRBESRRGNR1H4OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |