Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 13/20 | 0.63 |
| ▸ | GAA | P10253 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | SNCA | P37840 | 2/20 | 0.63 |
| ▸ | CYBB | P04839 | 2/20 | 0.63 |
| ▸ | NOX3 | Q9HBY0 | 2/20 | 0.63 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.63 |
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580166 | 0.85 | NOX1 (0.74) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL31491519 | 0.79 | NOX1 (0.74) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL3586011 | 0.79 | NOX1 (0.74) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL342449 | 0.77 | NOX1 (1.00) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL13269666 | 0.77 | NOX1 (0.63) | NOX1GAAMAPTMEN1KMT2A | |
| Phenothiazine SCHEMBL28073776 | 0.77 | NOX1 (1.00) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL29375737 | 0.77 | NOX1 (1.00) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL3583619 | 0.77 | NOX1 (0.58) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL24220378 | 0.76 | NOX1 (0.70) | NOX1GAAMAPTMEN1KMT2A | |
| SCHEMBL22960579 | 0.76 | KCNH2 (0.68) | NOX1GAAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8642591-B2 | Composition containing amidine derivatives or carboxamide derivatives and steroids, as a medicament | IPSEN PHARMA S.A.S. (FR) | 2014-02-04 | — | — | US | disclosed |
| CN-101291676-B | Amidine derivatives and their use as medicaments | SOD CONSEILS RECH APPLIC | 2011-09-14 | — | — | CN | disclosed |
| US-7659266-B2 | Amidine derivatives and their applications as a medicament | S.C.R.A.S. (FR) | 2010-02-09 | — | — | US | disclosed |
| US-20090149430-A1 | COMPOSITION CONTAINING AMIDINE DERIVATIVES OR CARBOXAMIDE DERIVATIVES AND STEROIDS, AS A MEDICAMENT | IPSEN PHARMA S.A.S. (FR) | 2009-06-11 | — | — | US | disclosed |
| US-20090018120-A1 | AMIDINE DERIVATIVES AND THEIR APPLICATIONS AS A MEDICAMENT | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (FR) | 2009-01-15 | — | — | US | disclosed |
| EP-1993555-A1 | COMPOSITION CONTAINING AMIDINE DERIVATIVES OR CARBOXAMIDE DERIVATIVES AND STEROIDS, AS A MEDICAMENT | Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS (FR) | 2008-11-26 | — | — | EP | disclosed |
| CN-101291676-A | Amidine derivatives and their use as medicaments | SOD CONSEILS RECH APPLIC (FR) | 2008-10-22 | — | — | CN | disclosed |
| EP-1954288-A1 | AMIDINE DERIVATIVES AND THEIR USES AS MEDICINE | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007101937-A1 | COMPOSITION CONTAINING AMIDINE DERIVATIVES OR CARBOXAMIDE DERIVATIVES AND STEROIDS, AS A MEDICAMENT | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2007-09-13 | — | — | WO | disclosed |
| CN-1317278-C | Heterocyclic compounds and their use as medicines | SOD CONSEILS RECH APPLIC (FR) | 2007-05-23 | — | — | CN | disclosed |
| WO-2007045761-A1 | AMIDINE DERIVATIVES AND THEIR USES AS MEDICINE | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2007-04-26 | — | — | WO | disclosed |
| EP-1661564-A1 | Heterocyclic compounds and their pharmaceutical use | Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) (FR) | 2006-05-31 | — | — | EP | disclosed |
| EP-1233962-B1 | NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE AS MEDICINES | SOD CONSEILS RECH APPLIC (FR) | 2006-03-01 | — | — | EP | disclosed |
| US-20040180936-A1 | Heterocyclic compounds and their use as medicaments | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIEQUES (S.C.R.A.S.) | 2004-09-16 | — | — | US | disclosed |
| US-6747024-B1 | INHIBITING CALPAIN AND/OR REACTIVE OXYGEN SPECIES IN WARM-BLOODED ANIMALS | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2004-06-08 | — | — | US | disclosed |
| CN-1391571-A | Heterocyclic compounds and their use as medicines | SOD CONSEILS RECH APPLIC (FR) | 2003-01-15 | — | — | CN | disclosed |
| EP-1233962-A2 | NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE AS MEDICINES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001032654-A2 | NOVEL HETEROCYCLIC COMPOUNDS AND THEIR USE AS MEDICINES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180936-A1 | Heterocyclic compounds and their use as medicaments | CAPN1, CAPN2, CAPNS1 | NOX1 21/4885GAA 527/4885MAPT 1874/4885 |
| US-20090149430-A1 | COMPOSITION CONTAINING AMIDINE DERIVATIVES OR CARBOXAMIDE DERIVATIVES AND STEROIDS, AS A MEDICAMENT | MC2R, CYP11B2, NR3C2 | NOX1 2535/4885GAA 3874/4885MAPT 2671/4885 |
| US-20090018120-A1 | AMIDINE DERIVATIVES AND THEIR APPLICATIONS AS A MEDICAMENT | CAPN2, CAPN9, CAPN1 | NOX1 196/4885GAA 340/4885MAPT 622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.