Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 2/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7926464 | 0.85 | KDR (0.42) | ALDH1A1CLCN2KDRPDK1TYK2 | |
| SCHEMBL3236266 | 0.85 | CLCN2 (0.50) | ALDH1A1CLCN2KDRPDK1TYK2 | |
| Hydrochloric Acid SCHEMBL3583525 | 0.83 | CLCN2 (0.49) | ALDH1A1CLCN2KDRPDK1TYK2 | |
| SCHEMBL927178 | 0.81 | KDR (0.42) | ALDH1A1CLCN2KDRPDK1TYK2 | |
| SCHEMBL21866058 | 0.81 | ALDH1A1 (0.47) | ALDH1A1DPP4CA2KMT2ANPSR1 | |
| SCHEMBL4536908 | 0.77 | ALDH1A1 (0.63) | ALDH1A1TYK2MEN1KMT2ANPSR1 | |
| SCHEMBL1313390 | 0.77 | ALDH1A1 (0.61) | ALDH1A1DPP4NOTUMMEN1HTT | |
| SCHEMBL28172626 | 0.76 | KCNQ3 (0.37) | ALDH1A1CLCN2KDRTYK2CES2 | |
| SCHEMBL10605032 | 0.74 | CLCN2 (0.41) | ALDH1A1CLCN2KDRCES2CTSS | |
| SCHEMBL8675762 | 0.74 | ALDH1A1 (0.52) | ALDH1A1DPP4CES2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513246-B2 | Use of N-heterocyclylmethylbenzamides in therapeutics | SANOFI (FR) | 2013-08-20 | — | — | US | disclosed |
| US-20100022548-A1 | USE OF N-HETEROCYCLYLMETHYLBENZAMIDES IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2010-01-28 | — | — | US | disclosed |
| US-7619089-B2 | Derivatives of N-heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics | SANOFI-AVENTIS (FR) | 2009-11-17 | — | — | US | disclosed |
| US-20080070941-A1 | DERIVATIVES OF N-HETEROCYCLYLMETHYLBENZAMIDES, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2008-03-20 | — | — | US | disclosed |
| US-7288656-B2 | Derivatives of N-heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics | SANOFI-AVENTIS (FR) | 2007-10-30 | — | — | US | disclosed |
| US-20060264441-A1 | Derivatives of N-heterocyclylmethylbenzamides, prepartion method thereof and application of same in therapeutics | SANOFI-AVENTIS (FR) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022548-A1 | USE OF N-HETEROCYCLYLMETHYLBENZAMIDES IN THERAPEUTICS | NMBR, EGLN2, KRAS | ALDH1A1 876/4885CLCN2 1163/4885KDR 1082/4885 |
| US-20080070941-A1 | DERIVATIVES OF N-HETEROCYCLYLMETHYLBENZAMIDES, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | HNMT, CCKBR, CNR2 | ALDH1A1 544/4885CLCN2 2971/4885KDR 2067/4885 |
| US-20060264441-A1 | Derivatives of N-heterocyclylmethylbenzamides, prepartion method thereof and application of same in therapeutics | HNMT, CCKBR, CNR2 | ALDH1A1 613/4885CLCN2 3627/4885KDR 3036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.