Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLCN2 | P51788 | 1/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 2/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3583525 | 0.98 | CLCN2 (0.49) | CLCN2DPP4ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3583523 | 0.85 | ALDH1A1 (0.47) | CLCN2DPP4ALDH1A1KDRKMO | |
| SCHEMBL979367 | 0.85 | CLCN2 (0.47) | CLCN2DPP4ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6728532 | 0.83 | DPP4 (0.47) | CLCN2DPP4ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL22208595 | 0.83 | CLCN2 (0.42) | CLCN2DPP4ALDH1A1KDRKMO | |
| SCHEMBL23832862 | 0.81 | CLCN2 (0.41) | CLCN2DPP4ALDH1A1KMODAO | |
| SCHEMBL7927678 | 0.81 | DPP4 (0.44) | CLCN2DPP4ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL784920 | 0.77 | TYK2 (0.55) | DPP4ALDH1A1TYK2RORC | |
| 2,3,6-Trichlorobenzoic Acid SCHEMBL29365114 | 0.77 | DPP4 (0.62) | DPP4ALDH1A1KDM4EHSD17B10NOTUM | |
| 2,3,6-Trichlorobenzoic Acid SCHEMBL117071 | 0.77 | DPP4 (0.62) | DPP4ALDH1A1KDM4EHSD17B10NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513246-B2 | Use of N-heterocyclylmethylbenzamides in therapeutics | SANOFI (FR) | 2013-08-20 | — | — | US | disclosed |
| US-7745642-B2 | Glycine transport inhibitors | GLAXO GROUP LIMITED (GB) | 2010-06-29 | — | — | US | disclosed |
| US-20100022548-A1 | USE OF N-HETEROCYCLYLMETHYLBENZAMIDES IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2010-01-28 | — | — | US | disclosed |
| US-7619089-B2 | Derivatives of N-heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics | SANOFI-AVENTIS (FR) | 2009-11-17 | — | — | US | disclosed |
| US-20090270510-A1 | GLYCINE TRANSPORT INHIBITORS | GLAXO GROUP LIMITED (GB) | 2009-10-29 | — | — | US | disclosed |
| EP-1838663-B1 | GLYCINE TRANSPORT INHIBITORS | GLAXO GROUP LTD (GB) | 2009-01-21 | — | — | EP | disclosed |
| US-20080287547-A1 | Glycine Transport Inhibitors | GLAXO GROUP LIMITED (GB) | 2008-11-20 | — | — | US | disclosed |
| US-20080070941-A1 | DERIVATIVES OF N-HETEROCYCLYLMETHYLBENZAMIDES, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2008-03-20 | — | — | US | disclosed |
| US-7288656-B2 | Derivatives of N-heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics | SANOFI-AVENTIS (FR) | 2007-10-30 | — | — | US | disclosed |
| EP-1841727-A1 | GLYCINE TRANSPORT INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-10-10 | — | — | EP | disclosed |
| EP-1838663-A1 | GLYCINE TRANSPORT INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-10-03 | — | — | EP | disclosed |
| US-20060264441-A1 | Derivatives of N-heterocyclylmethylbenzamides, prepartion method thereof and application of same in therapeutics | SANOFI-AVENTIS (FR) | 2006-11-23 | — | — | US | disclosed |
| WO-2006067423-A1 | GLYCINE TRANSPORT INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |
| WO-2006067417-A1 | GLYCINE TRANSPORT INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022548-A1 | USE OF N-HETEROCYCLYLMETHYLBENZAMIDES IN THERAPEUTICS | NMBR, EGLN2, KRAS | CLCN2 1163/4885DPP4 3571/4885ALDH1A1 876/4885 |
| US-20090270510-A1 | GLYCINE TRANSPORT INHIBITORS | SLC18A2, SLC6A5, SLC1A2 | CLCN2 960/4885DPP4 589/4885ALDH1A1 1358/4885 |
| US-20080070941-A1 | DERIVATIVES OF N-HETEROCYCLYLMETHYLBENZAMIDES, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS | HNMT, CCKBR, CNR2 | CLCN2 2971/4885DPP4 4494/4885ALDH1A1 544/4885 |
| US-20060264441-A1 | Derivatives of N-heterocyclylmethylbenzamides, prepartion method thereof and application of same in therapeutics | HNMT, CCKBR, CNR2 | CLCN2 3627/4885DPP4 4038/4885ALDH1A1 613/4885 |
| US-20080287547-A1 | Glycine Transport Inhibitors | SLC18A2, SLC6A5, SLC1A2 | CLCN2 870/4885DPP4 565/4885ALDH1A1 1356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.