Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | MELK | Q14680 | 1/20 | 0.49 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.49 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582942 | 0.85 | PARP1 (0.43) | PARP1AURKBAURKAPRKD3MAP4K4 | |
| SCHEMBL3584976 | 0.84 | ACVR1 (0.42) | PARP1AURKBAURKAPIM1CLK4 | |
| SCHEMBL3582857 | 0.83 | PARP1 (0.66) | PARP1AURKBDYRK3PRKD3MAP4K4 | |
| SCHEMBL3580352 | 0.83 | AURKB (0.68) | PARP1AURKBAURKADYRK3PRKD3 | |
| SCHEMBL7762888 | 0.82 | PDE7A (0.41) | PARP1AURKBPRKD3MAP4K4PIM1 | |
| SCHEMBL3582368 | 0.82 | AURKB (0.64) | PARP1AURKBAURKADYRK3PRKD3 | |
| SCHEMBL29411925 | 0.77 | PARP1 (0.72) | PARP1AURKBDYRK3PRKD3MAP4K4 | |
| SCHEMBL5621808 | 0.76 | PARP1 (0.72) | PARP1PARP2 | |
| SCHEMBL5621907 | 0.74 | PARP1 (0.66) | PARP1 | |
| SCHEMBL1741562 | 0.74 | ADRB1 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |