Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 6/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.40 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584970 | 0.84 | PARP1 (0.53) | PIM1PARP1AURKAAURKBCLK4 | |
| SCHEMBL3582864 | 0.83 | GRK6 (0.48) | JAK2ADRB1HTR1AHTR7PARP1 | |
| SCHEMBL3580358 | 0.83 | PARP1 (0.53) | ACVR1JAK2TGFBR1PIM1PIM3 | |
| SCHEMBL3582373 | 0.82 | PARP1 (0.49) | ACVR1PIM1PIM3PIM2PARP1 | |
| SCHEMBL5621810 | 0.76 | HTR3A (0.52) | PARP1AURKACLK4 | |
| SCHEMBL5621910 | 0.74 | HTR3A (0.48) | PIM1PARP1 | |
| SCHEMBL1741562 | 0.74 | ADRB1 (0.61) | ACVR1ADRB1TGFBR1HTR1AHTR7 | |
| SCHEMBL30798753 | 0.74 | ADRB1 (0.61) | ACVR1ADRB1TGFBR1HTR1AHTR7 | |
| SCHEMBL6582942 | 0.74 | PARP1 (0.43) | ACVR1ADRB1TGFBR1HTR7PIM1 | |
| SCHEMBL3587289 | 0.74 | AURKA (0.56) | JAK2PARP1AURKAAURKBCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |