Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.35 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576692 | 0.89 | ESRRG (0.37) | OPRM1OPRD1NR1H4C5AR1NR1I3 | |
| SCHEMBL3580374 | 0.88 | ESRRG (0.36) | OPRM1OPRD1NR1H4NR1I3ESRRG | |
| SCHEMBL3584126 | 0.87 | ESRRG (0.36) | OPRM1OPRD1NR1H4NR1I3ESRRG | |
| SCHEMBL3574285 | 0.87 | ESRRG (0.36) | OPRM1OPRD1NR1H4NR1I3ESRRG | |
| SCHEMBL3587153 | 0.87 | ESRRG (0.36) | OPRM1OPRD1NR1H4C5AR1NR1I3 | |
| SCHEMBL3580346 | 0.85 | ESRRG (0.35) | OPRM1OPRD1NR1H4CYP2C19NR1I3 | |
| SCHEMBL3580658 | 0.85 | RAF1 (0.39) | OPRM1OPRD1NR1H4C5AR1CYP2C19 | |
| SCHEMBL3575452 | 0.81 | KMT2A (0.42) | OPRM1OPRD1NR1H4C5AR1RAF1 | |
| SCHEMBL1397638 | 0.80 | HCRTR1 (0.37) | NR1I3HCRTR1HCRTR2 | |
| SCHEMBL3585932 | 0.80 | CCR9 (0.36) | OPRM1OPRD1NR1H4CHRNA7C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |