Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 2/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | ESRRB | O95718 | 1/20 | 0.34 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576692 | 0.89 | ESRRG (0.37) | ESRRGNR1H4ESRRBNR1I3HSP90AA1 | |
| SCHEMBL3580374 | 0.89 | ESRRG (0.36) | ESRRGNR1H4ESRRBNR1I3HSP90AA1 | |
| SCHEMBL3587153 | 0.88 | ESRRG (0.36) | ESRRGNR1H4ESRRBNR1I3HSP90AA1 | |
| SCHEMBL3584126 | 0.88 | ESRRG (0.36) | ESRRGNR1H4ESRRBNR1I3HSP90AA1 | |
| SCHEMBL3574285 | 0.88 | ESRRG (0.36) | ESRRGNR1H4ESRRBNR1I3HSP90AA1 | |
| SCHEMBL3586398 | 0.85 | PTGES (0.39) | ESRRGNR1H4NR1I3OPRM1OPRD1 | |
| SCHEMBL3580658 | 0.84 | RAF1 (0.39) | ESRRGNR1H4ESRRBHSP90AA1SIGMAR1 | |
| SCHEMBL1397638 | 0.81 | HCRTR1 (0.37) | NR1I3SIGMAR1 | |
| SCHEMBL3574238 | 0.81 | MLYCD (0.35) | HSP90AA1SIGMAR1OPRM1OPRD1TRPM8 | |
| SCHEMBL3585932 | 0.81 | CCR9 (0.36) | ESRRGNR1H4ESRRBNR1I3HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |