Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.38 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.38 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29761064 | 0.79 | ADORA2A (0.51) | ADORA2AADORA1CDK2 | |
| SCHEMBL30162646 | 0.78 | ADORA2A (0.60) | ADORA2AADORA1DHFRMAPK1ALDH1A1 | |
| SCHEMBL4459534 | 0.71 | ADORA2A (1.00) | ADORA2AADORA1DHFRALDH1A1HSD17B10 | |
| SCHEMBL21514162 | 0.69 | METAP2 (0.66) | MAPK1ALDH1A1PARP1PRKCIPDE4B | |
| SCHEMBL5748987 | 0.69 | DHFR (0.62) | ADORA2AHRH3DHFRALDH1A1HSD17B10 | |
| SCHEMBL23388343 | 0.69 | ADORA2A (0.61) | ADORA2AADORA1PIK3CAMETAP2 | |
| Benzene SCHEMBL25427466 | 0.69 | RET (0.52) | ADORA2AADORA1DHFRMAPK1PI4KA | |
| SCHEMBL29487078 | 0.68 | XDH (0.55) | ADORA2AADORA1DHFRALDH1A1TDP1 | |
| SCHEMBL1014920 | 0.68 | XDH (0.55) | ADORA2AADORA1DHFRALDH1A1TDP1 | |
| SCHEMBL10725446 | 0.67 | ALDH1A1 (0.41) | HRH3DHFRALDH1A1HSD17B10PI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190787-A1 | Modulators of Mitotic Kinases | CDK1, BUB1, BUB1B | ADORA2A 4496/4885ADORA1 4010/4885HRH3 2673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.