Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 5/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | PRKX | P51817 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3583177 | 0.81 | CA2 (0.37) | GRIA2GRIA1GRIA3GRIA4CA2 | |
| SCHEMBL3575925 | 0.70 | ALDH1A1 (0.40) | GRIA2GRIA1GRIA3GRIA4CA2 | |
| SCHEMBL3588752 | 0.64 | ALDH1A1 (0.46) | GRIA2GRIA1GRIA3GRIA4CA2 | |
| SCHEMBL2791341 | 0.61 | ALDH1A1 (0.37) | GRIA2GRIA1GRIA3GRIA4CA2 | |
| SCHEMBL3578225 | 0.60 | CA2 (0.46) | GRIA2GRIA1GRIA3GRIA4CA2 | |
| SCHEMBL13753857 | 0.57 | CA2 (0.41) | CA2CA12CA4CA7CA9 | |
| SCHEMBL8891388 | 0.57 | CA12 (0.61) | GRIA2GRIA1GRIA3GRIA4CA2 | |
| SCHEMBL5917510 | 0.57 | GRIA2 (0.63) | GRIA2GRIA1GRIA3GRIA4CA2 | |
| SCHEMBL23191245 | 0.56 | GRIA2 (0.46) | GRIA2GRIA1GRIA3GRIA4CA2 | |
| SCHEMBL3984666 | 0.56 | RET (1.00) | CA2CA12CA4CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100190778-A1 | 3,4-DIHYDROBENZO[1,2,3]THIADIAZINE-1,1-DIOXIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, MEDICAMENTS CONTAINING SAID DERIVATIVES AND THEIR USE | EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENTARSASAG (HU) | 2010-07-29 | — | — | US | disclosed |
| EP-2064197-A2 | 3,4-DIHYDROBENZO[1,2,3]THIADIAZINE-1,1-DIOXIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, MEDICAMENTS CONTAINING SAID DERIVATIVES AND THEIR USE | Egis Gyogyszergyar Nyilvánosan Múködó Részvénytársaság (HU) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008020256-A2 | 3,4-DIHYDROBENZO[1,2,3]THIADIAZINE-1,1-DIOXIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, MEDICAMENTS CONTAINING SAID DERIVATIVES AND THEIR USE | EGIS GYÓGYSZERGYÁR_Nyilvánosan Müködö Részvénytársaság (HU) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190778-A1 | 3,4-DIHYDROBENZO[1,2,3]THIADIAZINE-1,1-DIOXIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, MEDICAMENTS CONTAINING SAID DERIVATIVES AND THEIR USE | TDO2, DHODH, DHPS | GRIA2 1224/4885GRIA1 1215/4885GRIA3 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.