Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | CCKBR | P32239 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.44 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542987 | 0.87 | HPGDS (0.67) | HPGDSMMP2L3MBTL1CCKBRKLKB1 | |
| SCHEMBL1543187 | 0.87 | HPGDS (0.67) | HPGDSMMP2L3MBTL1CCKBRKLKB1 | |
| SCHEMBL2247214 | 0.87 | MMP2 (0.56) | MMP2MMP13KLKB1 | |
| SCHEMBL12356365 | 0.86 | GRN (0.47) | HPGDSMMP2L3MBTL1KLKB1NFKB1 | |
| SCHEMBL3588293 | 0.85 | HSP90AA1 (0.52) | MMP2MMP12CCKBRPADI4ADAMTS4 | |
| SCHEMBL3576509 | 0.83 | ADAMTS5 (0.62) | MMP2L3MBTL1HDAC1MMP12MMP13 | |
| SCHEMBL2247747 | 0.82 | KDM1A (0.53) | MMP2MMP12CCKBRPADI4ADAMTS4 | |
| SCHEMBL7741064 | 0.81 | MMP2 (0.54) | MMP2MMP12CCKBRNFKB1PSMB5 | |
| SCHEMBL7741059 | 0.81 | MMP2 (0.54) | MMP2MMP12CCKBRNFKB1PSMB5 | |
| SCHEMBL2246427 | 0.80 | HPGDS (0.52) | HPGDSMMP2MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | WYETH (US) | 2010-01-14 | — | — | US | disclosed |
| US-7553873-B2 | Glutamate aggrecanase inhibitors | WYETH (US) | 2009-06-30 | — | — | US | disclosed |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | WYETH (US) | 2007-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010012-A1 | GLUTAMATE AGGRECANASE INHIBITORS | ADAMTS5, ADAMTS1, ADAMTS7 | HPGDS 1417/4885MMP2 49/4885L3MBTL1 4308/4885 |
| US-20070043066-A1 | Glutamate aggrecanase inhibitors | ADAMTS5, ADAMTS1, ADAMTS7 | HPGDS 1417/4885MMP2 49/4885L3MBTL1 4308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.