Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 11/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3594400 | 1.00 | CHRNB2 (0.56) | CHRNB2CHRNA4LTA4HCHRNA3 | |
| SCHEMBL7901523 | 0.74 | LTA4H (0.79) | LTA4HCHRNA3 | |
| SCHEMBL4155746 | 0.74 | LTA4H (0.79) | LTA4HCHRNA3 | |
| SCHEMBL5332805 | 0.74 | LTA4H (0.79) | LTA4HCHRNA3 | |
| SCHEMBL10029394 | 0.74 | LTA4H (0.60) | LTA4HCHRNA3 | |
| SCHEMBL10029398 | 0.74 | LTA4H (0.60) | LTA4HCHRNA3 | |
| SCHEMBL3591384 | 0.73 | LTA4H (0.52) | LTA4HCHRNA3 | |
| SCHEMBL13436360 | 0.73 | LTA4H (0.51) | LTA4HCHRNA3 | |
| SCHEMBL3591768 | 0.73 | LTA4H (0.52) | LTA4HCHRNA3 | |
| SCHEMBL3591386 | 0.73 | LTA4H (0.52) | LTA4HCHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963276-B9 | N-LINKED ARYL HETEROARYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2012-09-26 | — | — | EP | disclosed |
| EP-1963276-B1 | N-LINKED ARYL HETEROARYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2012-06-20 | — | — | EP | disclosed |
| US-7674802-B2 | leukotriene A4 hydrolase inhibitors; biaryl nitrogen-attached heterocycles | DECODE GENETICS, EHF (IS) | 2010-03-09 | — | — | US | disclosed |
| US-20070142434-A1 | N-LINKED ARYL HETEROARYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE CHEMISTRY, INC. (US) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142434-A1 | N-LINKED ARYL HETEROARYL INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | LTA4H, LTB4R, LTC4S | CHRNB2 3387/4885CHRNA4 1984/4885LTA4H 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.