Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC25A | P30304 | 1/20 | 0.56 |
| ▸ | CDC25B | P30305 | 1/20 | 0.56 |
| ▸ | CDC25C | P30307 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.52 |
| ▸ | EIF4E | P06730 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28522857 | 0.83 | CYP19A1 (0.59) | ARCYP1A1CYP1B1EIF4EKDM4E | |
| SCHEMBL3605142 | 0.82 | CDC25A (0.69) | CDC25ACDC25BCDC25CARGAA | |
| SCHEMBL15588908 | 0.76 | CYP2A6 (0.58) | ARKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31245782 | 0.76 | CYP2A6 (0.58) | ARKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14797104 | 0.75 | EIF4E (0.67) | CDC25ACDC25BCDC25CEIF4EKDM4E | |
| SCHEMBL23743150 | 0.75 | CDC25A (0.68) | CDC25ACDC25BCDC25CGAACYP1A1 | |
| SCHEMBL23657533 | 0.74 | CDC25A (0.62) | CDC25ACDC25BCDC25CARGAA | |
| SCHEMBL23743157 | 0.73 | RAB9A (0.71) | CDC25ACDC25BCDC25CGAAKDM4E | |
| SCHEMBL3609748 | 0.73 | KDM4E (0.46) | CYP1A1CYP1B1EIF4EKDM4ECYP19A1 | |
| SCHEMBL28065324 | 0.72 | GRM5 (0.48) | L3MBTL1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101663298-A | Thiazole derivatives as modulators of g protein-coupled receptors | IRM LLC | 2010-03-03 | — | — | CN | disclosed |
| US-20100022592-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2010-01-28 | — | — | US | disclosed |
| US-20100022592-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2010-01-28 | — | — | US | disclosed |
| EP-2121675-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008103500-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2008-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022592-A1 | THIAZOLE DERIVATIVES AS MODULATORS OF G PROTEIN-COUPLED RECEPTORS | GPR119, GPR65, GPR180 | CDC25A 3955/4885CDC25B 3578/4885CDC25C 3834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.