Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 5/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2425390 | 0.84 | HSD11B1 (0.49) | SLC6A3HSD11B1DRD2 | |
| SCHEMBL13404311 | 0.81 | TACR1 (0.48) | HSD11B1TACR1 | |
| SCHEMBL3384526 | 0.81 | DRD2 (0.45) | DRD2MEN1KMT2A | |
| SCHEMBL5169875 | 0.79 | SLC6A4 (0.39) | SLC6A4SLC6A3SLC6A2CCR2DRD2 | |
| SCHEMBL3588034 | 0.79 | TACR1 (0.45) | SLC6A4SLC6A3SLC6A2HSD11B1CCR2 | |
| SCHEMBL2425376 | 0.79 | HSD11B1 (0.58) | HSD11B1MEN1KMT2ATACR1CYP2D6 | |
| SCHEMBL3585852 | 0.78 | HSD11B1 (0.45) | HSD11B1MEN1KMT2ATACR1 | |
| SCHEMBL21680273 | 0.78 | SLC6A3 (0.45) | SLC6A4SLC6A3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL28123227 | 0.77 | TACR1 (0.44) | SLC6A4SLC6A3SLC6A2HSD11B1MEN1 | |
| SCHEMBL28077549 | 0.77 | HSD11B1 (0.43) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383821-B2 | NK-1 and serotonin transporter inhibitors | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2013-02-26 | — | — | US | disclosed |
| US-20100087434-A1 | NK-1 and Serotonin Transporter Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2010-04-08 | — | — | US | disclosed |
| US-20070249607-A1 | NK-1 AND SEROTONIN TRANSPORTER INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2007-10-25 | — | — | US | disclosed |
| WO-2007121389-A2 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES AS NK-I AND SEROTONIN TRANSPORTER INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087434-A1 | NK-1 and Serotonin Transporter Inhibitors | SLC6A4, TPH1, SLC6A2 | SLC6A4 1/4885SLC6A3 6/4885PRKAB2 1642/4885 |
| US-20070249607-A1 | NK-1 AND SEROTONIN TRANSPORTER INHIBITORS | SLC6A4, TPH1, SLC6A2 | SLC6A4 1/4885SLC6A3 6/4885PRKAB2 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.