Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.53 |
| ▸ | NPC1 | O15118 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ULK1 | O75385 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20789009 | 0.93 | NPC1 (0.55) | SMN1; SMN2NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL20788996 | 0.93 | ULK1 (0.52) | SMN1; SMN2NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL23873646 | 0.91 | NPC1 (0.57) | SMN1; SMN2NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL6393394 | 0.88 | MAPT (0.52) | SMN1; SMN2NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL15702620 | 0.86 | TRPV6 (0.47) | SMN1; SMN2NPC1MAPTRAB9AALDH1A1 | |
| Maleic Acid SCHEMBL20788978 | 0.80 | NPC1 (0.56) | SMN1; SMN2NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL378949 | 0.77 | SMN1; SMN2 (0.62) | SMN1; SMN2NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL9460468 | 0.77 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1MAPTRAB9AALDH1A1 | |
| SCHEMBL4240613 | 0.76 | UBE2M (0.46) | SMN1; SMN2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1920755 | 0.75 | NPC1 (0.60) | SMN1; SMN2NPC1MAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | SCHERING CORPORATION | 2010-11-25 | — | — | US | disclosed |
| EP-2134713-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008082490-A2 | NOVEL JNK INHIBITORS | SCHERING CORPORATION (US) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100298314-A1 | NOVEL JNK INHIBITORS | MAPK1, MAPKAPK2, MAP4K2 | SMN1; SMN2 2617/4885NPC1 1606/4885MAPT 1863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.