SCHEMBL360524

SCHEMBL360524

C=C(C)C(=O)OC[Si](C)(OC)OC.C[SiH3]

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.42
ALDH1A1 P00352 2/20 0.42
THRB P10828 1/20 0.40
POLB P06746 1/20 0.30
APEX1 P27695 1/20 0.30
HTT P42858 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL145163 0.96 TSHR (0.45) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL28371093 0.89 TSHR (0.40) TSHRALDH1A1THRB
SCHEMBL395895 0.85 TSHR (0.40) TSHRALDH1A1THRB
SCHEMBL3206533 0.84 TSHR (0.37) TSHRALDH1A1THRB
SCHEMBL4445988 0.83 THRB (0.41) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL229519 0.80 TSHR (0.45) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL65596 0.78 THRB (0.50) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL332603 0.78 TSHR (0.44) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL5388461 0.78 TSHR (0.44) TSHRALDH1A1THRBPOLBAPEX1
SCHEMBL82401 0.78 TSHR (0.47) TSHRALDH1A1THRBPOLBAPEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2488557-A1 PROCESS FOR CONTINUOUS EMULSION POLYMERIZATION Wacker Chemie AG (DE) 2012-08-22 EP disclosed
WO-2012007356-A1 PROCESS FOR CONTINUOUS EMULSION POLYMERIZATION WACKER CHEMIE AG (DE) 2012-01-19 WO disclosed