Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 2/20 | 0.75 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.75 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | GRK6 | P43250 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7829487 | 0.86 | KEAP1 (0.73) | KEAP1NFE2L2BCAT2ALDH1A1MAPT | |
| SCHEMBL4930390 | 0.86 | KEAP1 (1.00) | KEAP1NFE2L2BCAT2ALDH1A1MAPT | |
| SCHEMBL41435 | 0.84 | KEAP1 (0.64) | KEAP1NFE2L2BCAT2PDK2ALDH1A1 | |
| SCHEMBL1512156 | 0.83 | KEAP1 (0.65) | KEAP1NFE2L2BCAT2PDK2ALDH1A1 | |
| SCHEMBL27925971 | 0.83 | KEAP1 (0.59) | KEAP1NFE2L2BCAT2PDK2ALDH1A1 | |
| SCHEMBL5866501 | 0.83 | KEAP1 (0.69) | KEAP1NFE2L2BCAT2PDK2ALDH1A1 | |
| SCHEMBL20695793 | 0.82 | MAPT (0.53) | KEAP1NFE2L2ALDH1A1MAPTLMNA | |
| SCHEMBL31012518 | 0.81 | BCAT2 (0.71) | KEAP1NFE2L2BCAT2PDK2ALDH1A1 | |
| SCHEMBL1110181 | 0.81 | BCAT2 (0.71) | KEAP1NFE2L2BCAT2PDK2ALDH1A1 | |
| SCHEMBL17183653 | 0.80 | KEAP1 (0.51) | KEAP1NFE2L2BCAT2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4568733-A | AIRCRAFT | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1986-02-04 | — | — | US | claimed |
| US-20100076005-A1 | ISOCARBOSTYRIL ALKALOID DERIVATIVES HAVING ANTI-PROLIFERATIVE AND ANTI-MIGRATORY ACTIVITIES | UNIBIOSCREEN SA (BE) | 2010-03-25 | — | — | US | disclosed |
| US-20090233960-A1 | Kinase Inhibitors | DEVGEN NV (BE) | 2009-09-17 | — | — | US | disclosed |
| EP-2089395-A2 | NEW ISOCARBOSTYRIL ALKALOID DERIVATIVES HAVING ANTI-PROLIFERATIVE AND ANTI-MIGRATORY ACTIVITIES | UnibioScreen S.A. (BE) | 2009-08-19 | — | — | EP | disclosed |
| CN-101287707-A | Kinase inhibitors | DEVGEN NV (BE) | 2008-10-15 | — | — | CN | disclosed |
| EP-1934181-A2 | KINASE INHIBITORS | Devgen NV (BE) | 2008-06-25 | — | — | EP | disclosed |
| WO-2008043846-A2 | NEW ISOCARBOSTYRIL ALKALOID DERIVATIVES HAVING ANTI-PROLIFERATIVE AND ANTI-MIGRATORY ACTIVITIES | UNIBIOSCREEN SA (BE) | 2008-04-17 | — | — | WO | disclosed |
| WO-2007042321-A2 | KINASE INHIBITORS | DEVGEN N.V. (BE) | 2007-04-19 | — | — | WO | disclosed |
| EP-0470180-B1 | HYDROXY-FUNCTIONAL POLY(AMIDE ETHERS) AS THERMOPLASTIC BARRIER RESINS | DOW CHEMICAL CO (US) | 1997-03-05 | — | — | EP | disclosed |
| US-5143998-A | HYDROXY-FUNCTIONAL POLY(AMIDE ETHERS) AS THERMOPLASTIC BARRIER RESINS | THE DOW CHEMICAL COMPANY (US) | 1992-09-01 | — | — | US | disclosed |
| EP-0470180-A4 | HYDROXY-FUNCTIONAL POLY(AMIDE ETHERS) AS THERMOPLASTIC BARRIER RESINS | — | 1992-07-15 | — | — | EP | disclosed |
| US-5112907-A | Polyphenylene Ether, Ethylene-A-Olefin Copolymer Rubber Grafted with Alkenyl Aromatic and Unsaturated Acid or Anhydride | SUMITOMO CHEMICAL CO., LTD. (JP) | 1992-05-12 | — | — | US | disclosed |
| US-5089588-A | From bisphenol A diglycidyl ether and N,N'-bis/m-hydroxy phenyl)adipamide | THE DOW CHEMICAL COMPANY (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0470180-A1 | HYDROXY-FUNCTIONAL POLY(AMIDE ETHERS) AS THERMOPLASTIC BARRIER RESINS. | DOW CHEMICAL CO (US) | 1992-02-12 | — | — | EP | disclosed |
| WO-1990012828-A1 | HYDROXY-FUNCTIONAL POLY(AMIDE ETHERS) AS THERMOPLASTIC BARRIER RESINS | THE DOW CHEMICAL COMPANY (US) | 1990-11-01 | — | — | WO | disclosed |
| US-4568733-A | AIRCRAFT | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1986-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233960-A1 | Kinase Inhibitors | ROCK1, MAP3K1, MAP3K11 | KEAP1 1077/4885NFE2L2 3386/4885BCAT2 3653/4885 |
| US-20100076005-A1 | ISOCARBOSTYRIL ALKALOID DERIVATIVES HAVING ANTI-PROLIFERATIVE AND ANTI-MIGRATORY ACTIVITIES | MIF, IMPDH1, IMPDH2 | KEAP1 3152/4885NFE2L2 3125/4885BCAT2 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.