Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 8/20 | 0.41 |
| ▸ | PRPS1 | P60891 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3597093 | 0.88 | BACE1 (0.47) | HTTALDH1A1LMNARECQLRAB9A | |
| SCHEMBL5345354 | 0.83 | TRPA1 (0.44) | HTTALDH1A1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL3602189 | 0.83 | HPGD (0.43) | ALDH1A1LMNAMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL5367271 | 0.81 | MTNR1A (0.53) | HTTALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL3606208 | 0.81 | TP53 (0.44) | HTTALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL3605821 | 0.81 | CCNE1 (0.43) | MAPTSMN1; SMN2CCNE1CDK2CDK5 | |
| SCHEMBL3599702 | 0.80 | GRIN2B (0.41) | ALDH1A1LMNARAB9ACCNE1CDK2 | |
| SCHEMBL3605623 | 0.77 | TRPA1 (0.43) | LMNARECQLSMN1; SMN2POLBMEN1 | |
| SCHEMBL3597269 | 0.77 | ENPP2 (0.45) | HTTLMNARECQLSMN1; SMN2ENPP2 | |
| SCHEMBL3608393 | 0.75 | PRPS1 (0.41) | HTTALDH1A1MITFLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7807704-B2 | Bicyclic, nitrogen-containing compounds modulating CXCR4 and/or CCXCKR2 | CHEMOCENTRYX, INC. (US) | 2010-10-05 | — | — | US | disclosed |
| US-20070275965-A1 | CXCR4 modulators | CHEMOCENTRYX, INC. (US) | 2007-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275965-A1 | CXCR4 modulators | CXCL12, CXCR4, CXCR1 | HTT 1553/4885ALDH1A1 662/4885MITF 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.