Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 2/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | GOT1 | P17174 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3607898 | 0.92 | MDM2 (0.46) | MDM4MDM2HDAC8TP53HTR2A | |
| SCHEMBL3598443 | 0.88 | HTR2A (0.42) | MDM4MDM2TP53HTR2AHTR1A | |
| SCHEMBL3604686 | 0.85 | DPP4 (0.41) | HDAC8TP53GOT1HTR2AHTR1D | |
| SCHEMBL3599723 | 0.84 | CNR1 (0.42) | MDM4MDM2TP53SLC6A2SLC6A4 | |
| SCHEMBL3594733 | 0.81 | CXCR2 (0.44) | MDM4MDM2TP53NPC1GAA | |
| SCHEMBL3595829 | 0.78 | CYP3A4 (0.44) | MDM4MDM2TP53RAB9A | |
| SCHEMBL3595338 | 0.78 | PNMT (0.41) | HTR6MAPT | |
| SCHEMBL3597273 | 0.77 | CXCR2 (0.40) | MDM4MDM2HDAC8TP53MEN1 | |
| SCHEMBL3599359 | 0.76 | CXCR2 (0.40) | MDM4MDM2HDAC8TP53MEN1 | |
| SCHEMBL3600935 | 0.76 | TP53 (0.45) | MDM4MDM2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728146-B2 | Enzyme inhibitors | PROBIODRUG AG (DE) | 2010-06-01 | — | — | US | claimed |