Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 5/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | MDM4 | O15151 | 3/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3598443 | 0.94 | HTR2A (0.42) | MDM2TP53MDM4SLC6A4HTR2A | |
| SCHEMBL3605880 | 0.92 | MDM4 (0.43) | MDM2TP53MDM4SLC6A4HTR2A | |
| SCHEMBL3596995 | 0.82 | SLC6A4 (0.41) | MDM2TP53MDM4SLC6A4HTR2A | |
| SCHEMBL3599723 | 0.81 | CNR1 (0.42) | MDM2TP53MDM4SLC6A4DPP4 | |
| SCHEMBL3088301 | 0.80 | HTR2A (0.46) | MDM2TP53MDM4SLC6A4HTR2A | |
| SCHEMBL3595401 | 0.78 | HTR2A (0.46) | MDM2TP53MDM4HTR2AGPR84 | |
| SCHEMBL3594733 | 0.78 | CXCR2 (0.44) | MDM2TP53MDM4DPP4DPP8 | |
| SCHEMBL3600935 | 0.78 | TP53 (0.45) | MDM2TP53MDM4DPP4DPP8 | |
| SCHEMBL3595338 | 0.77 | PNMT (0.41) | DPP4DPP8LMNAMAPT | |
| SCHEMBL3604686 | 0.77 | DPP4 (0.41) | TP53HTR2AGPR84CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728146-B2 | Enzyme inhibitors | PROBIODRUG AG (DE) | 2010-06-01 | — | — | US | claimed |