Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.41 |
| ▸ | MDM4 | O15151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 3/20 | 0.37 |
| ▸ | CCND1 | P24385 | 3/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 3/20 | 0.37 |
| ▸ | SSTR2 | P30874 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3607898 | 0.94 | MDM2 (0.46) | HTR2AMDM2MDM4TP53GPR84 | |
| SCHEMBL3605880 | 0.88 | MDM4 (0.43) | HTR2AMDM2MDM4TP53HTR1A | |
| SCHEMBL3595401 | 0.85 | HTR2A (0.46) | HTR2AMDM2MDM4TP53HTR1A | |
| SCHEMBL3599723 | 0.78 | CNR1 (0.42) | MDM2MDM4TP53SLC6A4 | |
| SCHEMBL3597074 | 0.77 | CNR1 (0.44) | TP53 | |
| SCHEMBL3088301 | 0.76 | HTR2A (0.46) | HTR2AMDM2MDM4TP53GPR84 | |
| SCHEMBL3596995 | 0.76 | SLC6A4 (0.41) | HTR2AMDM2MDM4TP53HTR2C | |
| SCHEMBL3594733 | 0.74 | CXCR2 (0.44) | MDM2MDM4TP53 | |
| SCHEMBL3600935 | 0.74 | TP53 (0.45) | MDM2MDM4TP53 | |
| SCHEMBL3595338 | 0.74 | PNMT (0.41) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728146-B2 | Enzyme inhibitors | PROBIODRUG AG (DE) | 2010-06-01 | — | — | US | claimed |