Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Oxyquinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | METAP2 | P50579 | 2/20 | 0.70 |
| ▸ | METAP1 | P53582 | 2/20 | 0.70 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | MMP2 | P08253 | 1/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.70 |
| ▸ | COMT | P21964 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxyquinoline SCHEMBL29729555 | 1.00 | ALDH1A1 (0.74) | ALDH1A1ALOX12LMNAMETAP2METAP1 | |
| Oxyquinoline SCHEMBL11199487 | 0.90 | ALDH1A1 (0.66) | ALDH1A1ALOX12LMNAMETAP2METAP1 | |
| Oxyquinoline SCHEMBL28459062 | 0.88 | MMP2 (0.84) | ALDH1A1ALOX12LMNAMETAP2METAP1 | |
| Oxyquinoline SCHEMBL28042473 | 0.86 | MMP2 (0.81) | ALDH1A1ALOX12LMNAMETAP2METAP1 | |
| Oxyquinoline SCHEMBL27477171 | 0.86 | MMP2 (0.81) | ALDH1A1ALOX12LMNAMETAP2METAP1 | |
| Oxyquinoline SCHEMBL28315442 | 0.86 | MMP2 (0.81) | ALDH1A1ALOX12LMNAMETAP2METAP1 | |
| Oxyquinoline SCHEMBL28191778 | 0.86 | TSHR (0.95) | ALDH1A1ALOX12LMNAMETAP2METAP1 | |
| Oxyquinoline SCHEMBL4456594 | 0.85 | ALDH1A1 (1.00) | ALDH1A1ALOX12LMNAMETAP2METAP1 | |
| Oxyquinoline SCHEMBL891989 | 0.85 | ALDH1A1 (1.00) | ALDH1A1ALOX12LMNAMETAP2METAP1 | |
| Oxyquinoline SCHEMBL4465896 | 0.84 | MMP2 (0.78) | ALDH1A1ALOX12LMNAMETAP2METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060198905-A1 | Pharmaceutical compositions comprising an extract of euphorbia prostrata | PANACEA BIOTEC PHARMA LIMITED (IN) | 2006-09-07 | — | — | US | claimed |
| EP-1628673-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING AN EXTRACT OF EUPHORBIA PROSTRATA | Panacea Biotec Limited (IN) | 2006-03-01 | — | — | EP | claimed |
| WO-2005065696-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING AN EXTRACT OF EUPHORBIA PROSTRATA | PANACEA BIOTEC LTD. (IN) | 2005-07-21 | — | — | WO | claimed |
| EP-1003791-A4 | ANTIMICROBIAL DENTURE ADHESIVE AND CLEANSER COMPOSITIONS | BLOCK DRUG CO (US) | 2004-12-08 | — | — | EP | claimed |
| EP-0868914-B1 | USE OF A FLAVONOID-CONTAINING EXTRACT OF THE PLANT EUPHORBIA PROSTRATA IN THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF AN ANORECTIC OR COLONIC DISEASE | PANACEA BIOTEC LTD (IN) | 2002-12-18 | — | — | EP | claimed |
| US-6124374-A | Antimicrobial denture adhesive and cleanser compositions | BLOCK DRUG COMPANY, INC. (US) | 2000-09-26 | — | — | US | claimed |
| EP-1003791-A1 | ANTIMICROBIAL DENTURE ADHESIVE AND CLEANSER COMPOSITIONS | BLOCK DRUG COMPANY INC. (US) | 2000-05-31 | — | — | EP | claimed |
| WO-1999061491-A1 | ANTIMICROBIAL DENTURE ADHESIVE AND CLEANSER COMPOSITIONS | BLOCK DRUG COMPANY, INC. (US) | 1999-12-02 | — | — | WO | claimed |
| EP-0868914-A1 | Pharmaceutical composition for the control and treatment of anorectal and colonic diseases | PANACEA BIOTEC LIMITED (IN) | 1998-10-07 | — | — | EP | claimed |
| US-4117013-A | AMINES, QUATERNARY AMMONIUM COMPOUNDS, OLEFIN EPOXIDES, HYDROXYQUI(OLINES, AMINE PHENOXIDES, GLYCIDYL HALIDES AND ETHERS | UNITED TECHNOLOGIES CORPORATION (US) | 1978-09-26 | — | — | US | claimed |
| US-20240373862-A1 | ANTIMICROBIAL NANO-EMULSION | LABORATOIRE M2 (CA) | 2024-11-14 | — | — | US | disclosed |
| WO-2024209263-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PURE EXTRACT OF EUPHORBIA PROSTRATA | MANKIND PHARMA LTD. (IN) | 2024-10-10 | — | — | WO | disclosed |
| US-12075788-B2 | Antimicrobial nano-emulsion | LABORATOIRE M2 (CA) | 2024-09-03 | — | — | US | disclosed |
| US-20240148918-A1 | Loading of Alginate Microspheres | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2024-05-09 | — | — | US | disclosed |
| EP-4301341-A1 | LOADING OF ALGINATE MICROSPHERES | Board of Regents, The University of Texas System (US) | 2024-01-10 | — | — | EP | disclosed |
| EP-0868914-A1 | Pharmaceutical composition for the control and treatment of anorectal and colonic diseases | PANACEA BIOTEC LIMITED (IN) | 1998-10-07 | — | — | EP | disclosed |
| US-5041275-A | Antimicrobial agents | UNION OIL COMPANY OF CALIFORNIA (US) | 1991-08-20 | — | — | US | disclosed |
| US-4797392-A | CHLOROPHYLLIN COMPOUNDS FOR HEMORRHOIDS | CHERNOMORSKY SIMON A (US) | 1989-01-10 | — | — | US | disclosed |
| WO-1988005298-A1 | USE OF ANORECTAL COMPOSITIONS | CHERNOMORSKY SIMON A | 1988-07-28 | — | — | WO | disclosed |
| US-3944669-A | 8-HYDROXY QUINOLINE DERIVATIVES | PEPRO (FR) | 1976-03-16 | — | — | US | disclosed |