Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxyquinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | MMP2 | P08253 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
| ▸ | COMT | P21964 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | METAP2 | P50579 | 1/20 | 0.68 |
| ▸ | METAP1 | P53582 | 1/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.58 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA6 | P23280 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxyquinoline SCHEMBL4456594 | 1.00 | ALDH1A1 (1.00) | ALDH1A1ALOX12LMNATSHRMMP2 | |
| Dipyridyl SCHEMBL28836737 | 0.93 | ALDH1A1 (0.86) | ALDH1A1ALOX12LMNATSHRMMP2 | |
| Phenanthroline SCHEMBL29020755 | 0.92 | ALDH1A1 (0.85) | ALDH1A1ALOX12LMNATSHRMMP2 | |
| Quinolinic Acid SCHEMBL28077234 | 0.86 | ALDH1A1 (0.76) | ALDH1A1ALOX12LMNATSHRMMP2 | |
| Oxyquinoline SCHEMBL28459062 | 0.86 | MMP2 (0.84) | ALDH1A1ALOX12LMNATSHRMMP2 | |
| Oxyquinoline SCHEMBL29729555 | 0.85 | ALDH1A1 (0.74) | ALDH1A1ALOX12LMNATSHRMMP2 | |
| Oxyquinoline SCHEMBL360625 | 0.85 | ALDH1A1 (0.74) | ALDH1A1ALOX12LMNATSHRMMP2 | |
| Oxyquinoline SCHEMBL28315442 | 0.84 | MMP2 (0.81) | ALDH1A1ALOX12LMNATSHRMMP2 | |
| Oxyquinoline SCHEMBL28042473 | 0.84 | MMP2 (0.81) | ALDH1A1ALOX12LMNATSHRMMP2 | |
| Oxyquinoline SCHEMBL27477171 | 0.84 | MMP2 (0.81) | ALDH1A1ALOX12LMNATSHRMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | claimed |
| WO-2024189607-A1 | METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR DISEASES TREATMENT | DIDENKO KIRILL (MX) | 2024-09-19 | — | — | WO | disclosed |
| US-20160166582-A1 | PROTEASOME INHIBITORS AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2016-06-16 | — | — | US | disclosed |
| US-9289433-B2 | Proteasome inhibitors and uses thereof | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2016-03-22 | — | — | US | disclosed |
| US-20140179645-A1 | ANTIMICROBIAL COMPOSITIONS | THE PISCES GROUP LLC (US) | 2014-06-26 | — | — | US | disclosed |
| WO-2014099461-A1 | ANTIMICROBIAL COMPOSITIONS | THE PISCES GROUP LLC (US) | 2014-06-26 | — | — | WO | disclosed |
| US-20130225547-A1 | PROTEASOME INHIBITORS AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO., LTD. (US) | 2013-08-29 | — | — | US | disclosed |
| CN-102639146-A | Proteasome inhibitors and uses thereof | YEDA RES & DEV | 2012-08-15 | — | — | CN | disclosed |
| US-20120083477-A1 | PROTEASOME INHIBITORS AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2012-04-05 | — | — | US | disclosed |
| WO-2010137017-A2 | PROTEASOME INHIBITORS AND USES THEREOF | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2010-12-02 | — | — | WO | disclosed |
| WO-2009140215-A2 | METHOD FOR TREATING DRUG-RESISTANT BACTERIAL AND OTHER INFECTIONS WITH CLIOQUINOL, PHANQUINONE, AND RELATED COMPOUNDS | GERAGHTY, ERIN (US) | 2009-11-19 | — | — | WO | disclosed |
| US-4410396-A | AMMONIUM FLUORIDE OR BIFLUORIDE, HYDROGEN PEROXIDE, ACID, 8-HYDROXYQUINOLINE | OCCIDENTAL CHEMICAL CORPORATION (US) | 1983-10-18 | — | — | US | disclosed |
| US-4022703-A | Stabilization of hydrogen peroxide in acid baths for cleaning metals | PRODUITS CHIMIQUES UGINE KUHLMANN (FR) | 1977-05-10 | — | — | US | disclosed |
| US-3944669-A | 8-HYDROXY QUINOLINE DERIVATIVES | PEPRO (FR) | 1976-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179645-A1 | ANTIMICROBIAL COMPOSITIONS | ERG28, GK, ACR | ALDH1A1 3290/4885ALOX12 624/4885LMNA 2418/4885 |
| US-20160166582-A1 | PROTEASOME INHIBITORS AND USES THEREOF | PSMB2, PSMB3, PSMB1 | ALDH1A1 2497/4885ALOX12 3517/4885LMNA 3688/4885 |
| US-20130225547-A1 | PROTEASOME INHIBITORS AND USES THEREOF | PSMB2, PSMB3, PSMB1 | ALDH1A1 2497/4885ALOX12 3517/4885LMNA 3688/4885 |
| US-20120083477-A1 | PROTEASOME INHIBITORS AND USES THEREOF | PSMB2, PSMB3, PSMB1 | ALDH1A1 2497/4885ALOX12 3517/4885LMNA 3688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.