Tetrahydrofuran

Tetrahydrofuran

SCHEMBL360933

C1CCOC1.COC(C)(C)C

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
USP2 O75604 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1921973 0.97 ALDH1A1 (0.47) ALDH1A1USP2SMN1; SMN2
Tetrahydrofuran SCHEMBL28159237 0.97 ALDH1A1 (0.47) ALDH1A1USP2SMN1; SMN2
Dioxane SCHEMBL1921978 0.87 ALDH1A1 (0.57) ALDH1A1USP2SMN1; SMN2
SCHEMBL1921976 0.81 ALDH1A1 (0.50) ALDH1A1
Tetrahydrofuran SCHEMBL2041223 0.79
Tetrahydrofuran SCHEMBL2514312 0.79 ALDH1A1 (0.47) ALDH1A1USP2SMN1; SMN2
Tetrahydrofuran SCHEMBL8787962 0.79 ALDH1A1 (0.47) ALDH1A1USP2SMN1; SMN2
Tetrahydrofuran SCHEMBL8787966 0.77 ALDH1A1 (0.44) ALDH1A1USP2SMN1; SMN2
Methoxymethane SCHEMBL9829152 0.76
Tetrahydrofuran SCHEMBL28446839 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 204 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117887031-A High molecular weight high biosafety sulfonamide polymer and preparation method thereof 智元柏迈(杭州)科技有限公司 2024-04-16 CN claimed
WO-2024046279-A1 POLYMORPH OF MAO-B INHIBITOR PRODRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF 广州市恒诺康医药科技有限公司 2024-03-07 WO claimed
CN-117623989-A Polymorphic form of MAO-B inhibitor prodrug, and preparation method and application thereof 广州市恒诺康医药科技有限公司 2024-03-01 CN claimed
CN-115397426-B Ebutinib glucolactone co-crystal and preparation method thereof 天津睿创康泰生物技术有限公司 2024-02-09 CN claimed
CN-115397426-A Ibutotinib glucolactone eutectic and preparation method thereof 天津睿创康泰生物技术有限公司 2022-11-25 CN claimed
CN-115385918-A Novel midazolam crystal form and preparation method thereof 成都硕德药业有限公司 2022-11-25 CN claimed
CN-115197075-A Preparation method of efavirenz key intermediate 盐城迪赛诺制药有限公司 2022-10-18 CN claimed
CN-113968791-A Preparation method of efavirenz key intermediate 盐城迪赛诺制药有限公司 2022-01-25 CN claimed
CN-113387944-B Synthetic method of rosuvastatin calcium intermediate 浙江宏元药业股份有限公司 2021-12-28 CN claimed
US-20210347736-A1 CRYSTALLINE FORMS OF A FARNESOID X RECEPTOR AGONIST METACRINE, INC. 2021-11-11 US claimed
US-20120115890-A1 SOLID FORMS COMPRISING 4-[9-(TETRAHYDRO-FURAN-3-YL)-8-(2,4,6-TRIFLUORO-PHENYLAMINO)-9H-PURIN-2-YLAMINO]-CYCLOHEXAN-1-OL, COMPOSITIONS THEREOF, AND USES THEREWITH BEAUCHAMPS MARIE G (US) 2012-05-10 US claimed
WO-2009060318-A2 POLYMORPHIC FORMS OF RAMELTEON AND PROCESSES FOR PREPARATION THEREOF TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2009-05-14 WO claimed
US-20090105490-A1 Polymorphic forms of ramelteon and processes for preparation thereof TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2009-04-23 US claimed
US-20090069593-A1 intermediates for synthesis of (S)-Pregabalin; anticonvulsants; crystalline form KANSAL VINOD KUMAR 2009-03-12 US claimed
EP-1863761-A1 PROCESS FOR PREPARING LEVETIRACETAM Rubamin Limited (IN) 2007-12-12 EP claimed
EP-1841726-A1 AN ASYMMETRIC SYNTHESIS OF ( S ) - ( + ) -3- (AMINOMETHYL) -5-METHYLHEXANOIC ACID Teva Pharmaceutical Industries Ltd (IL) 2007-10-10 EP claimed
US-20070197827-A1 Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2007-08-23 US claimed
WO-2007035890-A1 AN ASYMMETRIC SYNTHESIS OF ( S ) - ( + ) -3- (AMINOMETHYL) -5-METHYLHEXANOIC ACID TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2007-03-29 WO claimed
WO-2006095362-A1 PROCESS FOR PREPARING LEVETIRACETAM RUBAMIN LIMITED (IN) 2006-09-14 WO claimed
US-4900477-A Novel intermediates and an improved process for producing the compound (3β,5α)-3-hydroxycholest-8(14)-en-15-one AMERICAN CYANAMID COMPANY (US) 1990-02-13 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090105490-A1 Polymorphic forms of ramelteon and processes for preparation thereof CYP2D6, CYP2B6, CYP3A43 ALDH1A1 2850/4885USP2 3623/4885SMN1; SMN2 2457/4885
US-20070197827-A1 Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid RIMKLA, COASY, GABRE ALDH1A1 956/4885USP2 1113/4885SMN1; SMN2 3043/4885
US-20090069593-A1 intermediates for synthesis of (S)-Pregabalin; anticonvulsants; crystalline form GABRE, GABRA5, GABRA6 ALDH1A1 1019/4885USP2 2557/4885SMN1; SMN2 3238/4885
US-20120115890-A1 SOLID FORMS COMPRISING 4-[9-(TETRAHYDRO-FURAN-3-YL)-8-(2,4,6-TRIFLUORO-PHENYLAMINO)-9H-PURIN-2-YLAMINO]-CYCLOHEXAN-1-OL, COMPOSITIONS THEREOF, AND USES THEREWITH PYGL, OAT, VHL ALDH1A1 405/4885USP2 3624/4885SMN1; SMN2 91/4885
US-20210347736-A1 CRYSTALLINE FORMS OF A FARNESOID X RECEPTOR AGONIST NR1H4, NR1H3, NR1H2 ALDH1A1 3555/4885USP2 4033/4885SMN1; SMN2 4855/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.