Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 8/20 | 0.60 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.60 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.60 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.60 |
| ▸ | GSK3B | P49841 | 3/20 | 0.60 |
| ▸ | CDC7 | O00311 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | INSR | P06213 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | FLT1 | P17948 | 1/20 | 0.60 |
| ▸ | TYK2 | P29597 | 1/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
| ▸ | ITK | Q08881 | 1/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033029 | 0.81 | AGER (0.55) | CDK1CCNB1CCNB2CCNB3GSK3B | |
| SCHEMBL21908724 | 0.80 | ERN1 (0.54) | CDK1CCNB1CCNB2CCNB3GSK3B | |
| SCHEMBL3613255 | 0.79 | TEK (0.51) | KDR | |
| SCHEMBL21909262 | 0.79 | CDK1 (0.50) | CDK1CCNB1CCNB2CCNB3GSK3B | |
| SCHEMBL21908887 | 0.77 | ERN1 (0.52) | CDK1CCNB1CCNB2CCNB3GSK3B | |
| SCHEMBL3599233 | 0.77 | CDK9 (0.54) | CDK1CCNB1CCNB2CCNB3GSK3B | |
| SCHEMBL1031594 | 0.76 | EIF2AK2 (0.59) | CDK1CCNB1CCNB2CCNB3GSK3B | |
| SCHEMBL1034547 | 0.76 | EIF2AK2 (0.58) | CDK1CCNB1CCNB2CCNB3GSK3B | |
| SCHEMBL3620677 | 0.75 | SMN1; SMN2 (0.62) | CDK1CCNB1CCNB2CCNB3GSK3B | |
| SCHEMBL3775441 | 0.75 | CDK1 (1.00) | CDK1CCNB1CCNB2CCNB3GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048597-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-02-25 | — | — | US | disclosed |
| US-20100048597-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-02-25 | — | — | US | disclosed |
| US-20100048597-A1 | Organic Compounds and Their Uses | NOVARTIS AG | 2010-02-25 | — | — | US | disclosed |
| WO-2008079933-A2 | HETEROARYL-HETEROARYL COMPOUNDS AS CDK INHIBITORS FOR THE TREATMENT OF CANCER, INFLAMMATION AND VIRAL INFECTIONS | NOVARTIS AG (CH) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048597-A1 | Organic Compounds and Their Uses | OAT, OTC, AOX1 | CDK1 3769/4885CCNB1 3083/4885CCNB2 2524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.