Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 2/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 9/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.45 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | TSPO | P30536 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3611801 | 0.84 | MTNR1B (0.44) | MTNR1BMAPTSMN1; SMN2 | |
| SCHEMBL3601829 | 0.83 | GHSR (0.44) | TMEM97SIGMAR1MAPTLMNASMN1; SMN2 | |
| SCHEMBL3605947 | 0.82 | TMEM97 (0.38) | MTNR1BTMEM97SIGMAR1HTR1ACHRM5 | |
| SCHEMBL3607481 | 0.81 | TMEM97 (0.37) | MTNR1BTMEM97SIGMAR1HTR1ACHRM5 | |
| SCHEMBL3605570 | 0.78 | MTNR1B (0.48) | MTNR1BADRA1DADRA1AMAPT | |
| SCHEMBL3606133 | 0.76 | ACE (0.45) | MTNR1BTMEM97SIGMAR1HRH1HTR2B | |
| SCHEMBL3605484 | 0.75 | MTNR1B (0.46) | MTNR1BSIGMAR1MAPTLMNASMN1; SMN2 | |
| SCHEMBL3609218 | 0.69 | ACE (0.70) | MTNR1BDRD1 | |
| SCHEMBL3617388 | 0.69 | MTNR1B (0.41) | MTNR1BADRA1DADRA1AMAPT | |
| SCHEMBL2131896 | 0.68 | ALDH1A1 (0.60) | HTR7LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | KYOTO PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| EP-1857444-A1 | TETRAHYDROISOQUINOLINE COMPOUND AND MEDICINAL USE THEREOF | Kyoto Pharmaceutical Industries, Ltd. (JP) | 2007-11-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022582-A1 | Tetrahydroisoquinoline Compound and Medicinal Use Thereof | ACAT1, ACAT2, LCAT | MTNR1B 2142/4885TMEM97 2230/4885SIGMAR1 1494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.