Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | MGAM | O43451 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | SI | P14410 | 4/20 | 0.34 |
| ▸ | MGAM2 | Q2M2H8 | 4/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 2/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | PNP | P00491 | 1/20 | 0.31 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364494 | 0.90 | GPBAR1 (0.47) | GPBAR1BRD4MGAMGAASI | |
| SCHEMBL363678 | 0.87 | GPBAR1 (0.61) | GPBAR1BRD4MGAMGAASI | |
| SCHEMBL364601 | 0.84 | GPBAR1 (0.66) | GPBAR1BRD4MGAMGAASI | |
| SCHEMBL364092 | 0.84 | GPBAR1 (0.48) | GPBAR1BRD4MGAMGAASI | |
| SCHEMBL363349 | 0.84 | GPBAR1 (0.66) | GPBAR1BRD4MGAMGAASI | |
| SCHEMBL362545 | 0.84 | GPBAR1 (0.66) | GPBAR1BRD4MGAMGAASI | |
| SCHEMBL362350 | 0.83 | GPBAR1 (0.48) | GPBAR1BRD4CTSA | |
| SCHEMBL364071 | 0.81 | GPBAR1 (0.47) | GPBAR1BRD4 | |
| SCHEMBL1389894 | 0.81 | GPBAR1 (0.49) | GPBAR1BRD4 | |
| SCHEMBL1389891 | 0.81 | GPBAR1 (0.49) | GPBAR1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | claimed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | claimed |
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |