Sugi Predict

Sugi Predict / Compounds / SCHEMBL361933

SCHEMBL361933

SCHEMBL361933

O=C(c1ccccc1F)C(F)(F)F

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CES1 P23141 4/20 0.60
▸ CES2 O00748 3/20 0.60
▸ ALDH1A1 P00352 2/20 0.56
▸ ALOX15 P16050 1/20 0.56
▸ GAA P10253 1/20 0.50
▸ MEN1 O00255 2/20 0.48
▸ KMT2A Q03164 2/20 0.48
▸ TDP1 Q9NUW8 1/20 0.48
▸ MAPK1 P28482 1/20 0.47
▸ NPC1 O15118 2/20 0.47
▸ HPGD P15428 2/20 0.47
▸ MAPT P10636 1/20 0.47
▸ PTPN1 P18031 1/20 0.46
▸ ERCC5 P28715 1/20 0.46
▸ FEN1 P39748 1/20 0.46
▸ BCHE P06276 1/20 0.45
▸ HTT P42858 2/20 0.44
▸ LMNA P02545 1/20 0.44
▸ PLA2G2D Q9UNK4 1/20 0.42
▸ ALB P02768 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29668746 1.00 CES1 (0.60) CES1CES2ALDH1A1ALOX15GAA
SCHEMBL11254948 0.83 CES2 (0.56) CES1CES2ALDH1A1ALOX15GAA
SCHEMBL31084162 0.83 CES2 (0.56) CES1CES2ALDH1A1ALOX15GAA
SCHEMBL28520919 0.83 CES1 (0.56) CES1CES2ALDH1A1ALOX15GAA
SCHEMBL10448747 0.83 ALDH1A1 (0.57) CES1CES2ALDH1A1ALOX15GAA
SCHEMBL2194781 0.83 CES1 (0.63) CES1CES2ALDH1A1ALOX15GAA
SCHEMBL7937289 0.80 ALDH1A1 (0.59) CES1CES2ALDH1A1ALOX15GAA
SCHEMBL855691 0.80 CES2 (0.58) CES1CES2ALDH1A1ALOX15GAA
SCHEMBL28358179 0.79 CES1 (0.52) CES1CES2ALDH1A1ALOX15GAA
SCHEMBL7008611 0.79 CES1 (0.44) CES1CES2ALDH1A1ALOX15GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 125 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118307753-A Aryl piperidine type anion exchange membrane containing high-reactivity carbonyl monomer and preparation method thereof 大连理工大学 2024-07-09 — — CN claimed
EP-2547669-B1 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES BLUE CUBE IP LLC (US) 2015-11-25 — — EP claimed
EP-2547675-B1 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES DOW GLOBAL TECHNOLOGIES LLC (US) 2014-01-22 — — EP claimed
US-20130041165-A1 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES GULYAS GYONGYI (US) 2013-02-14 — — US claimed
EP-2547675-A2 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES Dow Global Technologies LLC (US) 2013-01-23 — — EP claimed
EP-2547669-A1 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES Dow Global Technologies LLC (US) 2013-01-23 — — EP claimed
US-20130005998-A1 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES BLUE CUBE IP LLC 2013-01-03 — — US claimed
CN-102432436-A Polyfluorophenyl substituted aromatic diphenol and its synthesis method and use CHINESE ACAD INST CHEMISTRY 2012-05-02 — — CN claimed
WO-2011116180-A1 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES DOW GLOBAL TECHNOLOGIES LLC (US) 2011-09-22 — — WO claimed
WO-2011116177-A2 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES DOW GLOBAL TECHNOLOGIES (US) 2011-09-22 — — WO claimed
CN-101307004-B Polyfluorphenyl substituted aromatic diamine, polymers thereof and method for preparing same CHINESE ACAD INST CHEMISTRY 2011-08-31 — — CN claimed
CN-101307004-A Polyfluorphenyl substituted aromatic diamine, polymers thereof and method for preparing same CHINESE ACAD INST CHEMISTRY (CN) 2008-11-19 — — CN claimed
CN-118307753-A Aryl piperidine type anion exchange membrane containing high-reactivity carbonyl monomer and preparation method thereof 大连理工大学 2024-07-09 — — CN disclosed
CN-117362281-A PI3K inhibitor and preparation method and application thereof 海创药业股份有限公司 2024-01-09 — — CN disclosed
CN-117003719-A Hydrogenated pyran ring compound containing exocyclic methylene and trifluoromethyl and preparation method thereof 安徽久易农业股份有限公司 2023-11-07 — — CN disclosed
US-11759462-B2 Spirocyclic compounds as tryptophan hydroxylase inhibitors ALTAVANT SCIENCES GMBH 2023-09-19 — — US disclosed
US-6242654-B1 REACTING A PHENOLATE COMPOUND WITH AN ORGANIC FLUORINATING AGENT TO PREPARE A FLUORINE SUBSTITUTED AROMATIC COMPOUND MITSUI CHEMICALS, INC. (JP) 2001-06-05 — — US disclosed
EP-1013629-A1 Preparation process of fluorine subsituted aromatic compound Mitsui Chemicals, Inc. (JP) 2000-06-28 — — EP disclosed
EP-0929533-A1 4,4-DISUBSTITUTED-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS AND INTERMEDIATES AND PROCESSES FOR MAKING THE SAME Du Pont Pharmaceuticals Company (US) 1999-07-21 — — EP disclosed
WO-1998014436-A1 4,4-DISUBSTITUTED-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS AND INTERMEDIATES AND PROCESSES FOR MAKING THE SAME DUPONT PHARMACEUTICALS COMPANY (US) 1998-04-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130041165-A1 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES SCO2, APEX1, SQLE CES1 3637/4885CES2 1436/4885ALDH1A1 1440/4885
US-20130005998-A1 PROCESS FOR PREPARING DIVINYLARENE DIOXIDES DAO, DDO, SCO2 CES1 2308/4885CES2 525/4885ALDH1A1 2650/4885
US-11759462-B2 Spirocyclic compounds as tryptophan hydroxylase inhibitors TPH1, TPH2, HTR1A CES1 495/4885CES2 3934/4885ALDH1A1 433/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.