Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.61 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.58 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3106241 | 0.95 | ADORA2B (0.58) | SIRT1SIRT3SIRT5ADORA2AADORA2B | |
| SCHEMBL3115718 | 0.92 | ADORA2A (0.55) | SIRT1SIRT3SIRT5ADORA2AADORA2B | |
| SCHEMBL3611280 | 0.91 | ADORA2A (0.60) | ADORA2AADORA2BADORA1KDM4EMEN1 | |
| SCHEMBL3121394 | 0.87 | ADORA2A (0.49) | SIRT1SIRT3SIRT5ADORA2AADORA2B | |
| SCHEMBL7031457 | 0.87 | SIRT1 (0.55) | SIRT1SIRT3SIRT5ADORA2AADORA2B | |
| SCHEMBL3119031 | 0.86 | ADORA2B (0.54) | SIRT1SIRT3SIRT5ADORA2AADORA2B | |
| SCHEMBL843582 | 0.86 | ADORA2B (0.54) | SIRT1SIRT3SIRT5ADORA2AADORA2B | |
| SCHEMBL3111070 | 0.85 | KDM4E (0.51) | ADORA2AADORA2BADORA1KDM4EALDH1A1 | |
| SCHEMBL3119443 | 0.85 | SIRT1 (0.54) | SIRT1SIRT3SIRT5ADORA2AADORA2B | |
| SCHEMBL836300 | 0.85 | ADORA2B (0.55) | ADORA2AADORA2BADORA1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100099690-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-04-22 | — | — | US | disclosed |
| US-20100099690-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-04-22 | — | — | US | disclosed |
| US-20100099690-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-04-22 | — | — | US | disclosed |
| EP-1912993-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SmithKline Beecham Corporation (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007017265-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099690-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | GPR84, GPR88, HCAR1 | SIRT1 1483/4885SIRT3 3159/4885SIRT5 1976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.