Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 4/20 | 1.00 |
| ▸ | EGFR | P00533 | 4/20 | 0.74 |
| ▸ | MAOA | P21397 | 1/20 | 0.71 |
| ▸ | MAOB | P27338 | 1/20 | 0.71 |
| ▸ | CA12 | O43570 | 2/20 | 0.66 |
| ▸ | CA1 | P00915 | 2/20 | 0.66 |
| ▸ | CA2 | P00918 | 2/20 | 0.66 |
| ▸ | CA9 | Q16790 | 2/20 | 0.66 |
| ▸ | ACHE | P22303 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | NT5E | P21589 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1658926 | 0.87 | NT5E (0.82) | KIF11EGFRMAOBACHENT5E | |
| SCHEMBL30751943 | 0.83 | MAOA (0.74) | KIF11EGFRMAOAMAOBCA12 | |
| SCHEMBL1659394 | 0.81 | MAPT (0.81) | KIF11EGFRMAOAMAOBCA1 | |
| SCHEMBL3624616 | 0.81 | NT5E (0.72) | KIF11EGFRMAOAMAOBACHE | |
| SCHEMBL28016739 | 0.81 | KIF11 (0.76) | KIF11MAOAMAOBCA12CA1 | |
| SCHEMBL28473652 | 0.80 | MAOB (0.79) | KIF11EGFRMAOAMAOBACHE | |
| SCHEMBL27790760 | 0.80 | MAOB (0.79) | KIF11MAOAMAOBACHENT5E | |
| SCHEMBL14133398 | 0.79 | MAOA (0.68) | KIF11EGFRMAOAMAOBCA12 | |
| SCHEMBL27276968 | 0.79 | KIF11 (0.74) | KIF11MAOAMAOBACHE | |
| SCHEMBL3314530 | 0.79 | MAOB (0.83) | EGFRMAOAMAOBACHEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745639-B2 | Mitotic kinesin inhibitors | MERCK & CO., INC. (US) | 2010-06-29 | — | — | US | claimed |
| EP-1492487-B1 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-11-11 | — | — | EP | claimed |
| EP-1492487-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2006-01-11 | — | — | EP | claimed |
| US-20050119484-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2005-06-02 | — | — | US | claimed |
| EP-1492487-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2005-01-05 | — | — | EP | claimed |
| WO-2003079973-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2003-10-02 | — | — | WO | claimed |
| US-7745639-B2 | Mitotic kinesin inhibitors | MERCK & CO., INC. (US) | 2010-06-29 | — | — | US | disclosed |
| EP-1492487-B1 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-11-11 | — | — | EP | disclosed |
| EP-1492487-A4 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2006-01-11 | — | — | EP | disclosed |
| US-20050119484-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2005-06-02 | — | — | US | disclosed |
| EP-1492487-A2 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003079973-A2 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119484-A1 | Mitotic kinesin inhibitors | KIF5B, KIF2C, KIF23 | KIF11 8/4885EGFR 3877/4885MAOA 4441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.