Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3621681 | 0.92 | MPO (0.48) | MPOMEN1KMT2AADRB2ADORA3 | |
| SCHEMBL3615064 | 0.85 | MPO (0.48) | MPOSIGMAR1MEN1KMT2AADRA1A | |
| SCHEMBL11580052 | 0.84 | ALOX15 (0.45) | POLB | |
| SCHEMBL3617344 | 0.81 | NR5A2 (0.49) | HRH3KDM4EGAAPOLB | |
| SCHEMBL3621893 | 0.80 | ALDH1A1 (0.42) | MPOMEN1KMT2APTGS2KDM4E | |
| SCHEMBL3614442 | 0.79 | NR5A2 (0.44) | MEN1KMT2AHRH3 | |
| SCHEMBL3624485 | 0.79 | NR5A2 (0.44) | MEN1KMT2AHRH3 | |
| SCHEMBL3619703 | 0.79 | NR5A2 (0.44) | MEN1KMT2AHRH3 | |
| SCHEMBL3622905 | 0.79 | ALDH1A1 (0.43) | MEN1KMT2AKDM4EGAA | |
| SCHEMBL3621214 | 0.78 | GSR (0.54) | KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517879-A4 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO INC (US) | 2006-09-13 | — | — | EP | claimed |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME LLC | 2005-10-20 | — | — | US | claimed |
| EP-1517879-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | Merck & Co., Inc. (US) | 2005-03-30 | — | — | EP | claimed |
| WO-2004000783-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO., INC. (US) | 2003-12-31 | — | — | WO | claimed |
| US-7834062-B2 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME CORP. (US) | 2010-11-16 | — | — | US | disclosed |
| US-20090298949-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK SHARP & DOHME LLC | 2009-12-03 | — | — | US | disclosed |
| US-7589127-B2 | Aminoalkylphenols, methods of using and making the same | MERCK & CO., INC. (US) | 2009-09-15 | — | — | US | disclosed |
| EP-1517879-A4 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO INC (US) | 2006-09-13 | — | — | EP | disclosed |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | MERCK SHARP & DOHME LLC | 2005-10-20 | — | — | US | disclosed |
| EP-1517879-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | Merck & Co., Inc. (US) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000783-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | MERCK & CO., INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090298949-A1 | AMINOALKYLPHENOLS, METHODS OF USING AND MAKING THE SAME | NPEPPS, PHOSPHO1, LNPEP | MPO 1816/4885SIGMAR1 1100/4885MEN1 2773/4885 |
| US-20050234265-A1 | Aminoalkylphenols, methods of using and making the same | NPEPPS, PHOSPHO1, LNPEP | MPO 1816/4885SIGMAR1 1100/4885MEN1 2773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.